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Updated: May 13, 2026
10:10
Preparation and Culture of Myogenic Precursor Cells/Primary Myoblasts from Skeletal Muscle of Adult and Aged Humans
Published on: February 16, 2017
Implications of multipotent mesenchymal stromal cell aging.
Ursula Stochaj1, Mohamed Kodiha, Dominique Shum-Tim
1Department of Physiology, McGill University, McIntyre Medical Sciences Building, Room 1115, 3655 Promenade Sir William Osler, Montréal, Québec H3G 1Y6, Canada.
Regenerative Medicine
|March 13, 2013
Summary
Aging involves functional decline and increased disease risk, driven by stem cell aging. This review explores how mesenchymal stromal cells contribute to aging and discusses nuclear changes in Hutchinson-Gilford progeria syndrome.
Area of Science:
- Gerontology and regenerative medicine.
- Cellular and molecular biology.
- Stem cell research.
Background:
- Aging is a complex process characterized by progressive functional impairment and increased susceptibility to disease.
- Declining regenerative capacity of resident stem cells is a key factor mediating organismal aging.
- Multipotent mesenchymal stromal cells (MSCs) play crucial roles in tissue repair and homeostasis.
Purpose of the Study:
- To review the evidence linking multipotent mesenchymal stromal cells to the aging process.
- To explore the role of MSCs as both affected by and contributors to tissue and organismal aging.
- To discuss specific nuclear alterations in premature aging syndromes like Hutchinson-Gilford progeria syndrome.
Main Methods:
- Literature review of studies on stem cell aging and mesenchymal stromal cells.
- Analysis of evidence implicating MSCs in age-related functional decline.
- Examination of nuclear changes in the context of Hutchinson-Gilford progeria syndrome.
Main Results:
- Evidence suggests MSCs undergo age-related changes that impair their function.
- MSCs contribute to aging through paracrine signaling and altered differentiation.
- Hutchinson-Gilford progeria syndrome exhibits distinct nuclear abnormalities in mesenchymal tissues.
Conclusions:
- Multipotent mesenchymal stromal cells are central players in both the aging process and its underlying mechanisms.
- Understanding MSC aging is critical for developing interventions against age-related diseases.
- Nuclear changes in MSCs, particularly in progeroid syndromes, offer insights into aging biology.
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