Related Experiment Video
Updated: May 13, 2026

An In Vitro Protocol for Evaluating MicroRNA Levels, Functions, and Associated Target Genes in Tumor Cells
Published on: May 21, 2019
Molecular targets in cancer therapy
Shivaani Kummar1, James H Doroshow
1Division of Cancer Treatment and Diagnosis and Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA. kummars@mail.nih.gov
Abstract:
24th EORTC-NCI-AACR Symposium on 'Molecular Targets and Cancer Therapeutics' 6-9 November 2012, Dublin, Ireland The EORTC-NCI-AACR Symposium is an annual meeting, jointly hosted by the European Organization for Research and Treatment of Cancer, the US National Cancer Institute and the American Association for Cancer Research, to encourage exchange of information, dialogue and collaboration between investigators from the US, Europe and the world over regarding the development of novel cancer therapeutics. This meeting is hosted on alternate years in the US and Europe. This year's symposium, held in Dublin, Ireland, focused on the identification of novel targets, strategies for biomarker development and trial designs to expedite development of new therapies and improve patient selection. With over 30 oral presentations, more than 600 poster presentations and over 2000 participants, the meeting covered all the major aspects of oncology drug development, including the integration of newer platforms for the development of biomarkers.
Related Concept Videos
Targeted Cancer Therapies
There are several types of targeted therapies against specific...
Targeted Cancer Therapies
There are several types of targeted therapies against specific...
Targets for Drug Action: Overview
Receptors are either membrane-spanning or intracellular proteins, which upon binding a ligand, get activated and transmit the signal downstream to elicit a response. Drugs bind receptors, either mimicking the action of endogenous ligands or blocking the receptor activity to bring about a modified response. Nearly 35% of approved drugs target the G...
Combination Therapies and Personalized Medicine
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Cancer
Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

