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Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder
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Cognition in late onset depression.

Marko Pišljar1, Grega Repovš, Zvezdan Pirtošek

  • 1Psychiatric Hospital Idrija, Pot sv. Antona 49, 5280 Idrija, Slovenia.

Psychiatry Research
|March 13, 2013
PubMed
Summary
This summary is machine-generated.

Cognitive impairments persist in late-onset depression patients even during remission. Event-related potentials and reaction times reveal persistent information processing deficits in these individuals.

Keywords:
CognitionEvent related potentialsLate onset depressionReaction timesStroop test

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Cognitive Psychology

Background:

  • Late-onset depression (LOD) is associated with cognitive deficits.
  • Cognitive function in LOD patients during remission requires further investigation.

Purpose of the Study:

  • To assess cognitive function in patients with LOD during a symptom-free remission period.
  • To investigate event-related potentials (ERPs) and reaction times (RTs) using the Stroop test in LOD patients in remission.

Main Methods:

  • A modified computer version of the Stroop Color-word task was administered to 34 patients with LOD in remission and matched healthy controls.
  • Electroencephalography (EEG) and RTs were simultaneously recorded during task performance.
  • Analysis focused on RTs and specific ERP components, including the P300b wave.

Main Results:

  • Patients with LOD exhibited significantly prolonged RTs across all Stroop conditions compared to controls.
  • A significantly greater Stroop interference effect was observed in LOD patients.
  • Abnormal late positive Stroop-related potentials (approx. 500-600 ms, P300b wave) were detected in the patient group.

Conclusions:

  • Cognitive impairments are present in LOD patients and persist into early remission.
  • ERP measurements of the Stroop task reveal impaired information processing at a pre-response stage in LOD patients during remission.