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Updated: May 13, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
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Published on: March 14, 2017

Exercise-related complications in sickle cell trait.

Julien Tripette1, Marie-Dominique Hardy-Dessources, Marc Romana

  • 1Department of Exercise Physiology, National Institute of Health and Nutrition, Shinjuku, Tokyo, Japan.

Clinical Hemorheology and Microcirculation
|March 13, 2013
PubMed
Summary

Exercise can cause complications in sickle cell trait carriers. This review examines potential causes like blood flow changes and inflammation, and factors influencing these exercise risks.

Keywords:
Sickle cell traitexercise-related sudden deathhemorheologyinflammationvascular function

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Area of Science:

  • Exercise physiology
  • Hematology
  • Sports medicine

Background:

  • Sickle cell trait (SCT) is a common inherited blood disorder.
  • Individuals with SCT are generally healthy but can experience exercise-related complications.
  • Understanding these risks is crucial for athlete safety.

Purpose of the Study:

  • To review epidemiological data on exercise complications in SCT carriers.
  • To explore the underlying mechanisms of these adverse events.
  • To discuss factors that modulate exercise risk in SCT.

Main Methods:

  • Literature review of epidemiological studies.
  • Analysis of proposed pathophysiological mechanisms.
  • Discussion of modulating factors.

Main Results:

  • Exercise-related complications in SCT carriers are documented.
  • Potential mechanisms include hemorheological alterations, inflammation, oxidative stress, and impaired nitric oxide metabolism.
  • Factors like heat, dehydration, fitness, and exercise intensity influence risk.

Conclusions:

  • Exercise complications in SCT carriers are multifactorial.
  • Further research is needed to fully elucidate mechanisms and optimize prevention strategies.
  • Awareness and management of modulating factors are key for athlete safety.