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Related Experiment Videos

Normal controls and biological reference values in child psychiatry: defining normal.

M J Kruesi1, M C Lenane, E D Hibbs

  • 1Child Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20892.

Journal of the American Academy of Child and Adolescent Psychiatry
|May 1, 1990
PubMed
Summary

Many child volunteers in psychiatric research are excluded due to mental health issues. Rigorous screening is essential to ensure healthy participants for accurate study results.

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Area of Science:

  • Child and Adolescent Psychiatry
  • Clinical Psychology
  • Neuroscience Research

Background:

  • Normal control subjects are crucial for biological psychiatric research.
  • Previous studies indicate high exclusion rates for adult controls due to psychopathology.
  • No comparable data exists for pediatric normal control subjects.

Purpose of the Study:

  • To determine the eligibility rate of pediatric volunteers for normal control research.
  • To assess the prevalence of psychiatric disorders among child volunteers.
  • To evaluate the effectiveness of screening methods for pediatric controls.

Main Methods:

  • Screening of 152 child volunteers (ages 6-18) for paid normal control roles.
  • Utilizing successive screenings, including rating scales and structured interviews.

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  • Assessing psychiatric health to meet defined standards for control subjects.

    • Main Results:

    • 44% of child applicants were found ineligible for the study.
    • At least 31.8% of child volunteers exhibited probable or certain psychiatric disorders.
    • Multiple screening stages were required to identify eligible participants.

    Conclusions:

    • A significant proportion of pediatric volunteers do not meet criteria for normal control subjects.
    • Stringent screening protocols are necessary for pediatric participants in psychiatric research.
    • Ensuring psychiatric health in child controls is vital for valid research comparisons.