Related Experiment Video
Updated: May 13, 2026

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A Preclinical Model of Exertional Heat Stroke in Mice
Published on: July 1, 2021
Specific exercise heat stress protocol for a triathlete's return from exertional heat stroke
Evan C Johnson1, Fred W Kolkhorst, Allen Richburg
1Department of Kinesiology, University of Connecticut, Storrs, CT 06269, USA. Evan.johnson@uconn.edu
Current Sports Medicine Reports
|March 13, 2013
Summary
Elite triathletes can safely return to competition after exertional heatstroke (EHS) with a tailored heat tolerance test (HTT) and acclimation program. This approach ensures athletes are heat-acclimated and ready for high-intensity racing.
Area of Science:
- Sports Medicine
- Environmental Physiology
- Exercise Science
Background:
- Exertional heatstroke (EHS) poses a significant risk for triathletes, necessitating careful return-to-play protocols.
- Traditional heat tolerance tests (HTT) may not adequately assess elite athletes' heat tolerance or acclimation capacity.
- Determining an elite triathlete's ability to compete after EHS requires evaluating their heat intolerance and acclimation potential.
Observation:
- A triathlete who experienced EHS underwent a modified HTT involving cycling at 70% V˙O2max in hot conditions (36°C, 50% RH).
- The protocol included 9 days of exercise heat acclimation followed by a repeat heat stress test.
- Key physiological markers monitored included gastrointestinal temperature (Tgi), exercise duration, and sweat rate.
Findings:
- Following heat acclimation, exercise duration before reaching a Tgi of 39.5°C increased by 25 minutes.
- Sweat rate increased by 0.5 L·h, initial Tgi decreased by 0.85°C, and the rate of Tgi rise decreased by 0.6°C·h.
- These physiological adaptations indicated improved heat tolerance and acclimation.
Implications:
- The modified HTT and acclimation strategy allowed the triathlete to safely return to competition.
- This approach provides a viable method for assessing heat tolerance in elite athletes post-EHS.
- It highlights the importance of individualized protocols for managing heat illness risk in sports.
Related Concept Videos
Exercise Stress Test
Introduction
Exercise stress testing, commonly known as a treadmill test, is a noninvasive procedure used to evaluate cardiovascular function and diagnose heart conditions.
Definition
An exercise stress test measures the heart's response to exertion using a treadmill or stationary bicycle. Chest electrodes record the heart's electrical activity through an ECG, and blood pressure is monitored regularly.
Purposes
Exercise stress testing, commonly known as a treadmill test, is a noninvasive procedure used to evaluate cardiovascular function and diagnose heart conditions.
Definition
An exercise stress test measures the heart's response to exertion using a treadmill or stationary bicycle. Chest electrodes record the heart's electrical activity through an ECG, and blood pressure is monitored regularly.
Purposes
Exercise and Cardiovascular Response
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Responses to Heat and Cold Stress
Every organism has an optimum temperature range within which healthy growth and physiological functioning can occur. At the ends of this range, there will be a minimum and maximum temperature that interrupt biological processes.
Homeostatic Imbalances in Body Temperature
Hyperthermia occurs when the body's temperature becomes unusually high, often due to heat exposure, intense physical activity, or certain illnesses. This condition can create a dangerous cycle where elevated body temperature increases the metabolic rate, generating more heat and potentially leading to organ failure and brain damage. A severe form of hyperthermia, called heat stroke, can raise body temperature to life-threatening levels. Fever, on the other hand, is a controlled form of...
Exercise and Cardiac Output
Regular physical activity is essential for maintaining cardiovascular health, with aerobic exercises being particularly effective. According to the American Heart Association, 150 minutes of moderate to intense aerobic exercise per week is recommended for a healthy heart. Aerobic activities may include brisk walking, running, bicycling, cross-country skiing, and swimming, ideally performed three to five times per week.
Sustained exercise increases the muscles' oxygen demand, which can be met...
Sustained exercise increases the muscles' oxygen demand, which can be met...
Methods of reducing fever
The signs and symptoms of fever include hot and dry skin, flushed face, thirst, muscle aches, anorexia, headache, tachycardia, tachypnea, and fatigue. Elevated body temperature is reduced using two methods: pharmacological and nonpharmacological. Proper identification and treatment of the root cause of a fever is of utmost importance.
Pharmacological Methods of Reducing Fever:
Pharmacological Methods of Reducing Fever:
