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Related Concept Videos

Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
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The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
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Blood and Nerve Supply to the Bones

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Updated: May 13, 2026

Identifying Bone Marrow Microenvironmental Populations in Myelodysplastic Syndrome and Acute Myeloid Leukemia
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Published on: November 10, 2023

Marrow: red, yellow and bad.

Robert Paul Guillerman1

  • 1E.B. Singleton Department of Pediatric Radiology, Texas Children's Hospital, 6701 Fannin St., Suite 470, Houston, TX 77030, USA. rpguille@texaschildrens.org

Pediatric Radiology
|March 13, 2013
PubMed
Summary
This summary is machine-generated.

This study details bone marrow MRI findings, explaining normal fat conversion and abnormal conditions. Recognizing these patterns aids in diagnosing bone marrow disorders and preventing misdiagnosis.

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Last Updated: May 13, 2026

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Area of Science:

  • Radiology
  • Orthopedic Imaging
  • Bone Marrow Imaging

Background:

  • Bone marrow is a large, dynamic tissue often overlooked in musculoskeletal imaging.
  • Inadequate attention to bone marrow on MRI increases the risk of missed or delayed diagnoses.
  • Understanding normal bone marrow changes is crucial for accurate interpretation.

Purpose of the Study:

  • To describe the physiological conversion of red to yellow bone marrow during childhood and adolescence.
  • To illustrate characteristic imaging findings of various bone marrow pathologies.
  • To guide radiologists in recognizing normal variants and pathological processes of the marrow compartment.

Main Methods:

  • Review of conventional MRI sequences depicting bone marrow.
  • Description of the spatiotemporal pattern of hematopoietic red marrow to fatty yellow marrow conversion.
  • Depiction of imaging findings associated with marrow hyperplasia, infiltration, deposition, depletion, and failure.

Main Results:

  • Normal conversion patterns of red to yellow marrow are detailed across different age groups.
  • Characteristic MRI findings for conditions like marrow hyperplasia/reconversion are presented.
  • Imaging features of marrow infiltration/deposition and depletion/failure are illustrated.

Conclusions:

  • Accurate interpretation of bone marrow MRI requires understanding normal physiological changes.
  • Familiarity with specific imaging patterns aids in diagnosing bone marrow disorders.
  • This guide enhances diagnostic accuracy for bone marrow pathologies on musculoskeletal imaging.