Related Experiment Video

Updated: May 13, 2026

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause

Published on: August 13, 2019

Interference of xenoestrogen o,p'-DDT on the action of endogenous estrogens at environmentally realistic

Lingying Zhong¹, Xiao Xiang, Wei Lu

¹School of Environmental Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, People's Republic of China.

Bulletin of Environmental Contamination and Toxicology

|March 13, 2013

Abstract:

Estrogenic effects of individual chemicals and mixtures of 17β-estradiol (E2) and o,p'-DDT were examined using pS2 and PR gene expressions in MCF-7 cells. Interactions between E2 and o,p'-DDT were evaluated by a statistical method based on factorial design. At levels close to environmentally realistic concentrations, no significant interactions between E2 and o,p'-DDT were observed, suggesting that the xenoestrogen (o,p'-DDT) could act in an additive way with the endogenous estrogen (E2). These results demonstrated the utility of this statistical method in a mixture study, and highlight the potential interference and health risk of low-level xenoestrogens, such as o,p'-DDT.

More Related Videos

Methods to Test Endocrine Disruption in Drosophila melanogaster

Methods to Test Endocrine Disruption in Drosophila melanogaster

Published on: July 3, 2019

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants

Published on: March 6, 2018

Related Concept Videos

Oogenesis

Oogenesis

In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...

Transducer Mechanism: Nuclear Receptors

Transducer Mechanism: Nuclear Receptors

Nuclear receptors, or NRs, are unique transcription factors that regulate gene transcription and affect the cellular pathways involved in reproduction, development, or metabolism. Their ability to be stimulated by small lipophilic ligands and control vital cellular processes makes them ideal drug targets. Nearly 10-15% of currently prescribed drugs target these receptors.
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:

Articles linked to this work by shared authors, journal, and citation graph.

Coronatine Subverts Tomato Immunity by Hijacking Hormonal Networks and Perturbing Physiological Homeostasis in Tomato Plants.

Plant disease·2026

Multimodal temporal feature fusion for teacher competency assessment and precision training resource recommendation.

Scientific reports·2026

Wnt signaling-mediated activation of cancer cell stemness in thoracic SMARCA4-deficient undifferentiated tumor cells.

Cell death discovery·2026

VLM-fusion: an intelligent diagnostic system for rural teacher professional development integrating vision-language models and adaptive learning path optimization.

Scientific reports·2026

Mineralization-based biochar unlocks sustainable restoration of soda saline-alkaline farmlands.

Nature communications·2026

Retrospective Analysis of the Molecular Links Among Clustered Cases of Acinetobacter baumannii Nosocomial Infections Occurring in Different Years within the ICU - Jiangsu Province, China, 2016-2021.

China CDC weekly·2026

See all related articles