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Updated: May 13, 2026

Forward Genetic Approaches in Chlamydia trachomatis
Published on: October 23, 2013
Activities of first-choice antimicrobials against gamma interferon-treated Chlamydia trachomatis differ in hypoxia
Kensuke Shima1, Matthias Klinger, Werner Solbach
1Institute of Medical Microbiology and Hygiene, University of Lübeck, Lübeck, Germany.
Abstract:
Gamma interferon (IFN-γ)-mediated host responses play a central role in resolving genital Chlamydia trachomatis infections but may also result in persistence of the pathogen, which shows reduced susceptibility to antimicrobials. The antichlamydial function of IFN-γ is oxygen dependent, and the efficacy of antimicrobials against C. trachomatis is reduced in a low-oxygen environment. In this study, we show that the antichlamydial efficacies of azithromycin and doxycycline differ in IFN-γ-treated cells under hypoxia.
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