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Related Concept Videos

Microbial Morphologies01:29

Microbial Morphologies

Bacterial and archaeal cells exhibit remarkable diversity in shape and structure, critical in their adaptability and functionality. Among bacteria, the most commonly observed shapes include cocci and bacilli. Cocci are spherical and may exist singly or in groupings such as pairs (diplococci), chains (streptococci), clusters (staphylococci), or tetrads. Bacilli, in contrast, are rod-shaped and can also occur as single cells, in pairs, or chains, depending on their environmental and genetic...

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Related Experiment Video

Updated: May 13, 2026

Cultivation Methods of Spirochetes from Borrelia burgdorferi Sensu Lato Complex and Relapsing Fever Borrelia
10:37

Cultivation Methods of Spirochetes from Borrelia burgdorferi Sensu Lato Complex and Relapsing Fever Borrelia

Published on: November 25, 2022

Borrelia burgdorferi tissue morphologies and imaging methodologies.

A B MacDonald1

  • 1Department of Biology and Environmental Science, Dr. Eva Sapi Borrelia Research Laboratory, University of New Haven, 1211 Campbell Ave., Charger Plaza, Suite 5, West Haven, CT 06516, USA. inmacdonald@yahoo.com

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
|March 13, 2013
PubMed
Summary
This summary is machine-generated.

Borrelia burgdorferi can appear in non-spiral tissue forms, often mistaken for artifacts. Recognizing these diverse Borrelia morphologies is crucial for accurate Lyme disease diagnosis and treatment assessment.

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Methods for Rapid Transfer and Localization of Lyme Disease Pathogens Within the Tick Gut

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Detecting the Lyme Disease Spirochete, Borrelia Burgdorferi, in Ticks Using Nested PCR
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Methods for Rapid Transfer and Localization of Lyme Disease Pathogens Within the Tick Gut
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Methods for Rapid Transfer and Localization of Lyme Disease Pathogens Within the Tick Gut

Published on: February 14, 2011

Area of Science:

  • Microbiology
  • Pathology

Background:

  • Borrelia burgdorferi, the causative agent of Lyme disease, is typically described as a spiral-shaped bacterium.
  • Non-spiral morphologies of Borrelia burgdorferi in host tissues are often overlooked or misidentified as artifacts.
  • Accurate identification of Borrelia in tissues is essential for diagnosing Lyme borreliosis and assessing treatment efficacy.

Purpose of the Study:

  • To present diverse, non-spiral forms of Borrelia burgdorferi observed in host tissues.
  • To provide explanations for the legitimacy of these tissue forms and differentiate them from artifacts.
  • To establish tissue examination as a diagnostic tool for Lyme borreliosis.

Main Methods:

  • Image presentation of Borrelia burgdorferi from personal collections and peer-reviewed literature.
  • Commentary and structural explanations for observed non-spiral morphologies (straightened, undulating, clipped-off).
  • Survey of imaging modalities used for Borrelia visualization.

Main Results:

  • Demonstration of various non-spiral Borrelia burgdorferi forms rarely seen in spiral shapes within solid tissues.
  • Explanation of the structural basis for these diverse morphological profiles.
  • Highlighting the diagnostic value of identifying these forms in tissue samples.

Conclusions:

  • Non-spiral Borrelia burgdorferi forms are legitimate and require recognition to avoid misdiagnosis.
  • Tissue examination serves as a critical diagnostic tool for Lyme borreliosis.
  • Objective assessment of borreliosis persistence or eradication post-antibiotic therapy can be achieved through tissue microbial detection.