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NIH toolbox for assessment of neurological and behavioral function.

Richard C Gershon1, Molly V Wagster, Hugh C Hendrie

  • 1Northwestern University Feinberg School of Medicine, Chicago, IL, USA. Gershon@northwestern.edu

Neurology
|March 13, 2013
PubMed
Summary

The NIH Toolbox provides uniform neurologic and behavioral assessments for diverse populations. These tools enable data pooling across studies, advancing neuroscience research.

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Area of Science:

  • Neuroscience
  • Behavioral Science
  • Biomedical Research

Background:

  • Existing neurologic and behavioral function measures lack uniformity, are costly, and often use homogenous, non-diverse populations.
  • Current assessment tools are not lifespan-spanning, may not align with current neuroscience understanding, and have limited pediatric motor/sensation measures, often relying on proxy reports.
  • Researchers need brief, standardized assessment tools for use across diverse studies and populations to facilitate data pooling and comparison.

Purpose of the Study:

  • To develop a set of state-of-the-art measurement tools for assessing neurologic and behavioral function.
  • To create a "common currency" for data collection across diverse study designs and populations.
  • To enhance data collection for large cohort studies and advance the biomedical research enterprise.

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Main Methods:

  • Development of the NIH Toolbox for the Assessment of Neurological and Behavioral Function.
  • Initiated by the NIH Blueprint for Neuroscience Research.
  • Focus on creating standardized, easily administered, and lifespan-spanning assessment tools.

Main Results:

  • The NIH Toolbox aims to provide a uniform metric for assessing neurologic and behavioral function.
  • Enables "crosswalking" across different measures, facilitating data pooling.
  • Addresses the need for brief, cost-effective, and normatively diverse assessment tools.

Conclusions:

  • Standardized assessment tools are crucial for comparing data across studies and pooling large, diverse datasets.
  • The NIH Toolbox enhances the ability to collect and analyze neurologic and behavioral data in large cohort studies.
  • This initiative supports the advancement of the biomedical research enterprise through improved data standardization.