Related Experiment Video

Updated: May 13, 2026

Monitoring of Nanodrug Accumulation in Murine Breast Cancer Metastases
09:48

Monitoring of Nanodrug Accumulation in Murine Breast Cancer Metastases

Published on: August 23, 2024

Metastamir-mediated immune evasion: miR-10b downregulates the stress-induced molecule MICB, hence avoid recognition

Pinchas Tsukerman1, Jonatan Enk, Ofer Mandelboim

  • 1Lautenberg Center for General and Tumor Immunology; The Hebrew University; The BioMedical Research Institute; Hadassah Medical School; Jerusalem, Israel.

Oncoimmunology
|March 13, 2013
PubMed

Insights

MicroRNA-10b (miR-10b) promotes cancer metastasis by inhibiting MICB, a molecule that activates natural killer (NK) cells. This mechanism helps tumors evade immune detection, contributing to cancer mortality.

Area of Science:

  • Oncology
  • Immunology
  • Molecular Biology

Background:

  • Metastasis is the primary cause of cancer-related mortality, accounting for over 90% of deaths.
  • Immune evasion is a critical hallmark of cancer, enabling tumor cells to survive and spread.
  • MICB, a ligand for the NKG2D receptor, plays a role in natural killer (NK) cell-mediated anti-tumor immunity.

Purpose of the Study:

  • To investigate the role of miR-10b in regulating MICB expression.
  • To elucidate the connection between miR-10b, MICB, and immune evasion in metastasis.
  • To understand the molecular mechanisms underlying cancer metastasis and immune escape.

Main Methods:

  • Analysis of miR-10b and MICB expression in metastatic cancer models.
  • Investigating the regulatory relationship between miR-10b and MICB.
  • Assessing the impact of miR-10b on NK cell activation and anti-tumor immunity.

Main Results:

  • miR-10b was found to inhibit the expression of MICB.
  • Suppression of MICB by miR-10b leads to reduced NK cell activation.
  • This pathway facilitates immune evasion and promotes metastasis formation.

Conclusions:

  • miR-10b-mediated inhibition of MICB is a key mechanism for cancer immune evasion.
  • Targeting this pathway could offer novel therapeutic strategies against metastasis.
  • Understanding miR-10b's role in immune evasion is crucial for improving cancer treatment outcomes.

More Related Videos

Two Flow Cytometric Approaches of NKG2D Ligand Surface Detection to Distinguish Stem Cells from Bulk Subpopulations in Acute Myeloid Leukemia05:24

Two Flow Cytometric Approaches of NKG2D Ligand Surface Detection to Distinguish Stem Cells from Bulk Subpopulations in Acute Myeloid Leukemia

Published on: February 21, 2021

Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
Receptor Downregulation in MVBs01:15

Receptor Downregulation in MVBs

Multivesicular bodies (MVBs) are mature endosomes that sort ubiquitinated proteins and then fuse with lysosomes to degrade the sorted proteins. Epidermal growth factor (EGF) and its receptor (EGFR) form a complex that can be internalized through endocytosis, sorted into an MVB, and later degraded.
The EGFR can initiate signaling pathways that  lead to cell proliferation, migration, and differentiation. Overexpression of EGFR  stimulates cells to proliferate. Excessive  EGFR activation may...
Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...