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Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides (CHIPS)
Published on: June 20, 2014
Chemo-enzymatic synthesis of pharmaceutical intermediates
1Bristol-Myers Squibb, Process Research and Development, New Brunswick, NJ 08903, USA +1 732 227 6213 ; patelr@bms.com.
Expert Opinion on Drug Discovery
|March 14, 2013
Summary
Enzymatic processes offer a powerful method for producing single enantiomers of pharmaceutical intermediates. These biocatalytic routes provide high selectivity, crucial for drug safety and efficacy.
Area of Science:
- Biocatalysis and Pharmaceutical Chemistry
Background:
- Chirality is critical for drug safety and efficacy.
- Producing single enantiomers of drug intermediates is vital for the pharmaceutical industry.
Purpose of the Study:
- To describe selected enzymatic processes for synthesizing chiral pharmaceutical intermediates.
- To highlight the potential of microorganisms and enzymes in chemical transformations.
Main Methods:
- Utilizing enzymes derived from microorganisms for chemical synthesis.
- Employing biocatalysis for chemo-, regio-, and enantioselective transformations.
Main Results:
- Demonstrated successful synthesis of chiral intermediates using enzymatic methods.
- Achieved high levels of selectivity in the transformation of synthetic chemicals.
Conclusions:
- Enzymatic processes are highly effective for producing enantiomerically pure pharmaceutical intermediates.
- Biocatalysis presents a promising and selective approach for the pharmaceutical industry.
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