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Related Experiment Video

Updated: May 13, 2026

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions

Published on: December 1, 2020

Building a drug-target network and its applications.

Soyoung Lee¹, Keunwan Park, Dongsup Kim

¹KAIST, Department of Bio and Brain Engineering, 335 Gwahak-ro, Yuseong-gu, Daejeon, 305-701 Korea, Republic of Korea +82 42 350 4317 ; +82 42 350 4310 ; kds@kaist.ac.kr.

Expert Opinion on Drug Discovery

|March 14, 2013

Summary

Building integrated networks of drugs, targets, and diseases is a key advance in drug discovery. These networks aid in identifying new drug targets and developing novel therapeutics.

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Published on: October 3, 2025

Area of Science:

Computational biology
Network science
Drug discovery

Background:

Network analysis is a recent development in drug discovery.
Integrating relationships among drugs, targets, diseases, and genes provides valuable insights.

Purpose of the Study:

Review recent network types and developments in drug discovery.
Suggest future directions for network studies in drug discovery.

Main Methods:

Integrating various databases and networks to form a comprehensive network.
Analyzing relationships between drugs, targets, genes, phenotypes, and diseases.
Discussing limitations and proposing strategies for building practical drug-target networks.

Main Results:

An integrated network can be constructed by addressing issues like limited coverage and inconsistency.
Network completion involves predicting missing links and identifying drug targets.
Biological network comparison aids in understanding relationships.

Conclusions:

Integrated networks offer applications in multi-target drug development and drug repurposing.
These networks can estimate drug effects on target perturbations.
They facilitate the extraction of suitable drug-target subnetworks for specific purposes.