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Updated: May 13, 2026

A Primary Neuron Culture System for the Study of Herpes Simplex Virus Latency and Reactivation
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A Primary Neuron Culture System for the Study of Herpes Simplex Virus Latency and Reactivation

Published on: April 2, 2012

Neonatal herpes simplex virus infections.

Swetha G Pinninti1, David W Kimberlin

  • 1Division of Pediatric Infectious Diseases, The University of Alabama at Birmingham, Birmingham, AL 35233, USA.

Pediatric Clinics of North America
|March 14, 2013
PubMed
Summary
This summary is machine-generated.

Neonatal herpes simplex virus (HSV) infection is rare but serious. Advances in polymerase chain reaction (PCR) diagnosis and antiviral treatments have greatly improved outcomes for affected infants.

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Published on: January 23, 2014

Area of Science:

  • Neonatal infectious diseases
  • Virology
  • Pediatric neurology

Background:

  • Neonatal herpes simplex virus (HSV) infections, though uncommon, pose significant risks of morbidity and mortality.
  • These infections are a critical consideration in the differential diagnosis of critically ill neonates.
  • The clinical presentation can be diverse, necessitating a high index of suspicion.

Purpose of the Study:

  • To summarize the epidemiology of neonatal HSV infections.
  • To discuss the clinical presentation, diagnosis, and management strategies.
  • To review follow-up care for infants diagnosed with neonatal herpes disease.

Main Methods:

  • Review of current literature on neonatal HSV epidemiology, clinical features, and management.
  • Emphasis on the diagnostic utility of polymerase chain reaction (PCR) for central nervous system (CNS) infections.
  • Evaluation of the impact of antiviral therapy and suppressivetherapy on patient outcomes.

Main Results:

  • Polymerase chain reaction (PCR) has revolutionized the diagnosis of CNS infections in neonates.
  • Safe and effective antiviral therapies have significantly improved management.
  • Long-term antiviral suppressivetherapy has led to substantial reductions in morbidity.

Conclusions:

  • Early diagnosis and prompt initiation of antiviral treatment are crucial for improving outcomes in neonatal HSV infections.
  • Advances in diagnostic tools like PCR and effective therapies have transformed the management landscape.
  • Long-term suppressivetherapy plays a vital role in mitigating long-term complications.