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Related Concept Videos

Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra. Symptoms...
Spermatogenesis01:41

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Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male reproductive...
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Infertility in Males

Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...

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Related Experiment Video

Updated: May 13, 2026

Flow Cytometric Analysis of Biomarkers for Detecting Human Sperm Functional Defects
08:48

Flow Cytometric Analysis of Biomarkers for Detecting Human Sperm Functional Defects

Published on: April 21, 2022

Sperm DNA fragmentation in men with malignancy.

Simon McDowell1, Keith Harrison, Ben Kroon

  • 1Queensland Fertility Group Research Foundation, Brisbane, Queensland, Australia. simon.mcdowell@hotmail.co.uk

Fertility and Sterility
|March 14, 2013
PubMed
Summary
This summary is machine-generated.

Men with cancer undergoing sperm cryopreservation showed no increased sperm DNA fragmentation compared to sperm donors. Sperm DNA fragmentation testing may have limited use in routine evaluation for semen cryopreservation.

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Area of Science:

  • Reproductive Medicine
  • Oncology
  • Genetics

Background:

  • Sperm DNA fragmentation (DFI) is a marker of sperm damage.
  • Cancer diagnosis and treatments can potentially impact sperm quality.
  • Evaluating DFI in men with cancer seeking fertility preservation is important.

Purpose of the Study:

  • To compare sperm DNA fragmentation in men with cancer undergoing prophylactic cryopreservation versus men seeking sperm donation.
  • To assess the utility of sperm DNA fragmentation index (DFI) in this population.

Main Methods:

  • Retrospective observational study at a tertiary fertility center.
  • Compared 89 men with cancer to 35 sperm donors.
  • Measured sperm DNA fragmentation index (DFI) using sperm chromatin assay.

Main Results:

  • Mean DFI was 9.88% in men with cancer and 10.46% in sperm donors, with no significant difference.
  • No significant DFI differences were found within cancer subgroups or between testicular and non-testicular cancers.
  • Men with testicular cancer had significantly reduced sperm concentration compared to controls and non-testicular cancer patients.

Conclusions:

  • Sperm DFI did not differ between men with cancer and sperm donors in this study.
  • Sperm DFI assessment has limited utility for routine evaluation in men undergoing semen cryopreservation.
  • Further research with larger sample sizes is needed for subgroup analyses.