Related Experiment Video
Updated: May 13, 2026
08:22
Retroviral Overexpression of CXCR4 on Murine B-1a Cells and Adoptive Transfer for Targeted B-1a Cell Migration to the Bone Marrow and IgM Production
Published on: May 31, 2020
Inflammatory response: role of B1 cells
Francisco Garcia Soriano1, Hermes Vieira Barbeiro, Denise Frediani Barbeiro
1Clinical Emergency, Department of Internal Medicine, Universidade de São Paulo, São Paulo, Brazil.
Shock (Augusta, Ga.)
|March 14, 2013
Summary
B1 cells play a dual role in immune responses. While sometimes detrimental in infections, they offer protection against endotoxemia by reducing mortality through IL-10 and IgM secretion.
Area of Science:
- Immunology
- Infectious Diseases
- Cell Biology
Background:
- Inflammation is a critical immune response, but exaggerated inflammation can be fatal.
- Macrophages and neutrophils are key early responders, with recent evidence highlighting lymphocyte involvement.
- B1 lymphocytes, implicated in X-linked agammaglobulinemia (XLA), have a complex role in immune responses.
Purpose of the Study:
- To analyze the role of B1 cells in inflammatory responses of various origins.
- To focus on the specific involvement of B1 cells in sepsis and endotoxemia.
Main Methods:
- Review of existing literature on B1 cell function in different inflammatory models.
- Analysis of B1 cell activity in experimental endotoxemia induced by lipopolysaccharide (LPS).
Main Results:
- B1 cell deficiency is linked to acute infections due to impaired adaptive immunity.
- B1 cells can be detrimental in models like Chagas disease, leishmaniasis, and S. aureus arthritis.
- B1 cells demonstrate a protective role in endotoxemia, reducing mortality.
Conclusions:
- B1 cells exhibit context-dependent roles, being protective in endotoxemia but potentially harmful in other infections.
- In endotoxemia, B1 cells contribute to interleukin-10 and immunoglobulin M secretion, mitigating host damage.
- Understanding B1 cell function is crucial for developing targeted therapies for inflammatory conditions and sepsis.
Related Concept Videos
01:30Inflammatory Response I: Vascular and Cellular
The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
01:24B Cell Activation and Differentiation
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
01:28Inflammatory Response
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
01:24T Cell Types and Functions
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
01:26Acute Inflammation I: Inflammatory Response
Acute inflammation is a rapid, short-lived physiological response to tissue injury or infection, designed to eliminate harmful agents and initiate repair. This tightly regulated process typically lasts from minutes to several days and is triggered by factors such as microbial invasion, physical trauma, or chemical injury.Recognition and Mediator ReleaseThe inflammatory response begins when resident immune cells—such as mast cells, macrophages, and dendritic cells—detect damage-associated...
01:31Defense Against Bacterial Pathogens
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...