Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Diabetic Retinopathy

Diabetic Retinopathy

DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...

Smooth Endoplasmic Reticulum

Smooth Endoplasmic Reticulum

Smooth endoplasmic reticulum or smooth ER is a sub-organelle with specialized functions in animal cells and plant cells. It is often associated with the tubule morphology of the endoplasmic reticulum.
The ER provides optimal conditions for synthesizing steroid hormones and lipids, such as phospholipids and triglycerides. Traditionally, lipid metabolism was considered to be a smooth ER function. However, there is no direct evidence to prove that rough ER is completely excluded from lipid...

The Retinoblastoma Gene

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Beyond the Stethoscope: Robotic Empathy in Pediatric Cardiology. The Emerging Role of Social Robots. A Pilot Study.

Pediatric cardiology·2026

Same author

Exploring the impact of rehabilitation on post-surgical recovery in elbow fracture patients: a cohort study.

Musculoskeletal surgery·2024

Same author

A focus on melorheostosis disease: a literature review and case report of femoral-acetabular impingement due to melorheostosis treated with surgical hip osteoplasty.

Reumatismo·2024

Same author

How to reduce erroneous Emergency Department admissions for the frail elderly.

Annali di igiene : medicina preventiva e di comunita·2023

Same author

Partial trapeziectomy and pyrocarbon interpositional implant (Pyrodisk) for trapeziometacarpal osteoarthritis in the active working population: outcomes of a 10 years-experience.

Journal of plastic surgery and hand surgery·2021

Same author

Consensus paper on postural dysfunction: recommendations for prevention, diagnosis and therapy.

Journal of biological regulators and homeostatic agents·2021

Same journal

Suppression of macrophage enriched miRNA 210-3p improves cardiac fibrosis and cardiac function following myocardial infarction.

Clinical hemorheology and microcirculation·2026

Same journal

Downregulation of PCAF inhibits vascular smooth muscle cells senescence by reducing oxidative stress injury via activating the Nrf2/ARE pathway.

Clinical hemorheology and microcirculation·2026

Same journal

Blood viscosity values for predicting pathological stroke types (ischemic stroke, hemorrhagic stroke, and stroke mimic) at DR. Cipto Mangunkusumo National Referral Hospital.

Clinical hemorheology and microcirculation·2026

Same journal

Adaptations of blood fluidity markers to progressive resistance training in men.

Clinical hemorheology and microcirculation·2026

Same journal

Changes in whole blood viscosity in patients undergoing percutaneous or surgical intervention for aortic stenosis.

Clinical hemorheology and microcirculation·2026

Same journal

Impairment of cutaneous microcirculation and vasoreactivity in primary hypothyroidism.

Clinical hemorheology and microcirculation·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 13, 2026

Retinal Cryo-sections, Whole-Mounts, and Hypotonic Isolated Vasculature Preparations for Immunohistochemical Visualization of Microvascular Pericytes

Retinal Cryo-sections, Whole-Mounts, and Hypotonic Isolated Vasculature Preparations for Immunohistochemical Visualization of Microvascular Pericytes

Published on: October 7, 2018

Microvascular abnormalities in Rett syndrome.

G Bianciardi, M Acampa, I Lamberti

Clinical Hemorheology and Microcirculation

|March 14, 2013

Summary

This summary is machine-generated.

Rett syndrome (RTT) is a neurological disorder. Microvascular abnormalities, including chaotic blood vessel patterns, are identified in RTT patients, offering new insights into the condition.

More Related Videos

Retinal Pathophysiological Evaluation in a Rat Model

Retinal Pathophysiological Evaluation in a Rat Model

Published on: May 6, 2022

Measuring Retinal Vessel Diameter from Mouse Fluorescent Angiography Images

Measuring Retinal Vessel Diameter from Mouse Fluorescent Angiography Images

Published on: May 19, 2023

Related Experiment Videos

Last Updated: May 13, 2026

Retinal Cryo-sections, Whole-Mounts, and Hypotonic Isolated Vasculature Preparations for Immunohistochemical Visualization of Microvascular Pericytes

Retinal Cryo-sections, Whole-Mounts, and Hypotonic Isolated Vasculature Preparations for Immunohistochemical Visualization of Microvascular Pericytes

Published on: October 7, 2018

Retinal Pathophysiological Evaluation in a Rat Model

Retinal Pathophysiological Evaluation in a Rat Model

Published on: May 6, 2022

Measuring Retinal Vessel Diameter from Mouse Fluorescent Angiography Images

Measuring Retinal Vessel Diameter from Mouse Fluorescent Angiography Images

Published on: May 19, 2023

Area of Science:

Neurology
Vascular Biology
Medical Imaging

Background:

Rett syndrome (RTT) is a significant cause of intellectual disability, characterized by neurological and non-neurological symptoms.
Non-neurological features like cold extremities and cyanosis in RTT patients remain poorly understood.
Videocapillaroscopy is utilized to investigate microvascular alterations in RTT.

Discussion:

Observed microvascular changes include ramified, bushy, and dilated capillaries, indicative of neoangiogenesis.
A chaotic and irregular microvascular pattern was detected in individuals with Rett syndrome.
Fractal analysis quantified these abnormalities, revealing significantly higher fractal dimension and Lempel-Ziv indexes in RTT patients compared to controls.

Key Insights:

This study reveals previously unrecognized microvascular abnormalities in Rett syndrome patients.
The findings suggest a link between vascular dysregulation and the non-neurological phenotypes of RTT.
Quantitative analysis using fractal geometry provides objective measures of microvascular complexity.

Outlook:

Further research into the mechanisms underlying these microvascular changes is warranted.
Understanding these abnormalities may lead to novel therapeutic strategies for Rett syndrome.
This work opens new avenues for diagnosing and managing RTT by focusing on vascular health.