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Related Experiment Videos

Sulfide concentrations in postmortem mammalian tissues.

T Nagata1, S Kage, K Kimura

  • 1Department of Forensic Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.

Journal of Forensic Sciences
|May 1, 1990
PubMed
Summary

Postmortem sulfide levels in rat tissues like liver and kidneys increase over time after death. Human tissue data largely mirrors rat findings, with blood showing minimal sulfide increase.

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Area of Science:

  • Forensic Science
  • Toxicology
  • Biochemistry

Background:

  • Hydrogen sulfide (H2S) is a toxic gas with implications in forensic investigations.
  • Understanding postmortem sulfide dynamics in tissues is crucial for interpreting toxicological findings.

Purpose of the Study:

  • To investigate postmortem changes in sulfide concentrations in various rat tissues.
  • To compare these changes with those in nonexposed rats and human tissues.
  • To assess the influence of hydrogen sulfide exposure on postmortem sulfide levels.

Main Methods:

  • Autopsied rats exposed to hydrogen sulfide (550-650 ppm) and nonexposed rats and humans were analyzed.
  • Gas chromatography following extractive alkylation was used for sulfide quantification.
  • Sulfide concentrations were measured in blood, liver, kidneys, lungs, brain, and muscle.

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Main Results:

  • Sulfide concentrations increased over time postmortem in rat blood, liver, and kidneys, regardless of H2S exposure.
  • Rat lungs, brain, and muscles showed minimal postmortem sulfide changes.
  • Human tissue results paralleled rat findings, with the exception of blood, which exhibited little to no postmortem sulfide increase.

Conclusions:

  • Postmortem sulfide accumulation varies significantly across different tissues.
  • Tissue-specific postmortem sulfide changes can be influenced by hydrogen sulfide exposure.
  • Findings provide insights into the postmortem behavior of sulfide in forensic toxicology.