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Published on: January 2, 2026
Autonomic cardiovascular dysfunction and vitamin D deficiency in pediatric spinal cord injury
Kathy Zebracki1, Miriam Hwang, Pamela L Patt
1Shriners Hospitals for Children, Chicago, IL 60707, USA. kzebracki@shrinenet.org
Insights
Pediatric spinal cord injury (SCI) patients often have autonomic cardiovascular issues and vitamin D deficiency. Routine monitoring of blood pressure, heart rate, and vitamin D is crucial for managing these complications.
Area of Science:
- Pediatric neurology
- Clinical research
- Public health
Background:
- Autonomic cardiovascular dysfunction and vitamin D deficiency are significant complications in pediatric spinal cord injury (SCI).
- Pilot studies are essential for understanding the prevalence and impact of these conditions in young patients.
Purpose of the Study:
- To provide an overview and preliminary findings on autonomic cardiovascular dysfunction and vitamin D deficiency in pediatric SCI.
- To highlight the clinical significance of these complications and inform management strategies.
Main Methods:
- Retrospective cross-sectional analysis of blood pressure (BP), heart rate (HR), and vitamin D levels.
- Data collected from a cohort of children and adolescents with SCI.
Main Results:
- In 279 children with SCI, BP increased and HR decreased with age; boys had higher systolic BP, girls had higher HR.
- No significant associations were found between BP/HR and injury level, severity, or duration.
- Among 82 youth with SCI, 79% exhibited vitamin D deficiency or insufficiency, with adolescents more affected than younger children.
Conclusions:
- Routine assessment of BP and HR is recommended for youth with SCI due to the risk of autonomic dysreflexia and orthostatic hypotension.
- Given the high prevalence of vitamin D insufficiency, routine monitoring of serum 25-hydroxycholecalciferol levels is advised to prevent complications like pathological fractures.
Objective:
The purpose of this manuscript is to present a general overview and preliminary results of pilot projects of two complications in pediatric spinal cord injury (SCI): autonomic cardiovascular dysfunction and vitamin D deficiency.
Methods:
Retrospective cross-sectional investigations of blood pressures (BP), heart rates (HR), and vitamin D levels were performed.
Results:
Among 279 children with SCI, it was observed that baseline BP increases and HR decreases with increasing age. Boys had higher systolic BP and girls had higher HR, but a gender difference in diastolic BP did not emerge. There were no significant associations of baseline BP or HR as a function of injury level, severity, or duration. Among 82 youth with SCI, 79% had vitamin D deficiency or insufficiency. There were no differences in vitamin D status as a function of gender or level of injury. Adolescents, however, were more likely to exhibit deficiency compared to children.
Implications:
Because of the clinical significance of autonomic dysreflexia and orthostatic hypotension, baseline BP and HR need to be routinely assessed in youth with SCI. In view of the high prevalence of vitamin D insufficiency in youth with SCI and the risk of complications such as pathological fractures, serum 25-hydroxycholecalciferol levels should be routinely monitored.
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