[Blood antioxidant enzyme activity during physiological and preeclampsia syndrome complicated pregnancy]

The aim of the study was determination of the role of oxidative metabolism in the pathogenesis of preeclampsia. It is established that in the blood of women during physiological pregnancy, catalase and glutathione reductase (gr) activity does not change significantly, compared with the same parameters in healthy nonpregnant women, superoxiddismutase (SOD) activity slightly increases, which indicates on the intensification of the oxidative processes in late term pregnancy. Intensification of oxidative processes during physiological pregnancy reviles the activation of the regulatory processes in the body directed to the induction placental cells proliferation and differentiation. During preeclampsia complicated pregnancy the catalase activity increases and SOD and GR activity decreases compared with the same parameters during physiological pregnancy; at the same time in patients blood superoxidradicals (О2-) are detected (by EPR method). Development of the chronic oxidative stress during preeclampsia may be related to disorders reperfusion-oxygenation of placenta tissue with following decreasing of the trophoblasts invasion, angiogenesis, disorders of placental metabolisms, reactivity of blood vessels, and increasing deepness of the preeclampsia.