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Related Concept Videos

Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
Venous Thrombosis I: Introduction01:30

Venous Thrombosis I: Introduction

Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
Venous Thrombosis IV: Nursing Management01:30

Venous Thrombosis IV: Nursing Management

Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...
Varicose Veins I: Introduction01:26

Varicose Veins I: Introduction

Varicose veins, or varicosities, are abnormally dilated and twisted superficial veins caused by venous valve incompetence. This condition commonly affects the lower extremities, especially the saphenous veins, due to the higher pressure from prolonged standing and walking. However, varicosities can also occur in other areas, such as the esophagus, vulva, spermatic cords, and anorectal region.Etiology and typesPrimary varicose veins, often idiopathic, are more common in women due to inherent...
Varicose Veins II: Diagnostic Studies and Interprofessional Care01:26

Varicose Veins II: Diagnostic Studies and Interprofessional Care

Varicose veins, or varicosities, develop when the valves in the veins, which control blood flow, weaken or damage. It causes blood to pool and the veins to enlarge. Understanding the clinical manifestations, diagnostic approaches, and management options for varicose veins is crucial for effective treatment and relief.Clinical manifestationsClinical manifestations of varicose veins include a heavy, achy feeling or pain after prolonged standing or sitting. This discomfort can often be relieved by...
Inflammation01:38

Inflammation

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Related Experiment Video

Updated: May 13, 2026

Deep Vein Thrombosis Induced by Stasis in Mice Monitored by High Frequency Ultrasonography
06:44

Deep Vein Thrombosis Induced by Stasis in Mice Monitored by High Frequency Ultrasonography

Published on: April 13, 2018

Inflammation in chronic venous ulcers.

J D Raffetto1

  • 1VA Boston Healthcare System, 1400 VFW Parkway, Surgery 112, West Roxbury, MA 02135, USA. joseph.raffetto@med.va.gov

Phlebology
|March 14, 2013
PubMed
Summary

Chronic venous ulcers (CVUs) affect 1% of people, increasing with age. Their development involves venous hypertension and inflammation, impacting wound healing and healthcare costs.

Area of Science:

  • Vascular Medicine
  • Dermatology
  • Wound Healing Research

Background:

  • Chronic venous ulcers (CVUs) affect approximately 1% of the general population.
  • Prevalence of chronic venous disease (CVD), including leg ulcers, increases with age.
  • CVD significantly impacts healthcare resources, causing substantial economic burden due to lost workdays and treatment costs.

Purpose of the Study:

  • To summarize the epidemiology, risk factors, economic impact, and pathophysiology of chronic venous ulcers.
  • To highlight the complex mechanisms underlying dermal abnormalities in CVUs.
  • To provide a foundation for understanding delayed wound healing in CVUs.

Main Methods:

  • Literature review and synthesis of existing data on CVUs and CVD.

More Related Videos

In vivo Imaging Method to Distinguish Acute and Chronic Inflammation
07:10

In vivo Imaging Method to Distinguish Acute and Chronic Inflammation

Published on: August 16, 2013

Related Experiment Videos

Last Updated: May 13, 2026

Deep Vein Thrombosis Induced by Stasis in Mice Monitored by High Frequency Ultrasonography
06:44

Deep Vein Thrombosis Induced by Stasis in Mice Monitored by High Frequency Ultrasonography

Published on: April 13, 2018

In vivo Imaging Method to Distinguish Acute and Chronic Inflammation
07:10

In vivo Imaging Method to Distinguish Acute and Chronic Inflammation

Published on: August 16, 2013

  • Analysis of epidemiological trends and risk factors associated with CVD.
  • Examination of the pathophysiological processes involved in CVU development.

    • Main Results:

    • CVUs are common, with prevalence rising with age.
    • Key risk factors include heredity, age, female sex, and obesity.
    • Pathophysiology involves venous hypertension, inflammation, microcirculatory changes, and altered cellular function.

    Conclusions:

    • CVUs represent a significant public health challenge with considerable economic implications.
    • Understanding the complex pathophysiology is crucial for developing effective treatments.
    • Further research is needed to address the delayed wound healing associated with CVUs.