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Strictly lobar microbleeds are associated with executive impairment in patients with ischemic stroke or transient

Simone M Gregoire1, Grit Scheffler, Hans R Jäger

  • 1Department of Brain Repair and Rehabilitation, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, United Kingdom.

Stroke
|March 14, 2013
PubMed
Abstract

Insights

Strictly lobar cerebral microbleeds (CMBs) are linked to executive dysfunction in stroke patients. These microbleeds, often seen in cerebral amyloid angiopathy, may contribute to cognitive impairment after ischemic events.

Area of Science:

  • Neurology
  • Neuroimaging
  • Cognitive Science

Background:

  • Cerebral microbleeds (CMBs) are indicators of small vessel diseases.
  • Their association with cognitive function in ischemic cerebrovascular disease is not fully understood.

Purpose of the Study:

  • To investigate the impact of CMBs on cognitive function in patients with ischemic stroke or transient ischemic attack.

Main Methods:

  • Comprehensive neuropsychological testing and standardized MRI were performed on 320 patients.
  • CMBs, white matter changes, lacunes, and infarcts were identified and correlated with cognitive assessments.

Main Results:

  • 22.5% of patients had at least one CMB.
  • Executive impairment was more common in patients with CMBs (38% vs. 25%).
  • Strictly lobar CMBs, but not deep CMBs, were significantly associated with executive dysfunction.

Conclusions:

  • Strictly lobar CMBs are independently associated with executive dysfunction in patients with ischemic stroke or transient ischemic attack.
  • Microangiopathy related to lobar CMBs, such as cerebral amyloid angiopathy, may contribute to cognitive impairment in this population.

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