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Alveolar cleft defect closure with iliac bone graft, rhBMP-2 and rhBMP-2 with zygoma shavings: Comparative study
1Balaji Dental and Craniofacial Hospital, Teynampet, Chennai, India.
Aim:
To present the outcome measures of the use of iliac bone graft, rhBMP-2 and rhBMP-2 with zygoma shavings in alveolar cleft defect closure.
Materials And Methods:
Retrospective analysis of details of treated alveolar defect cases (5-10 years during January 2008-December 2010) from records with 4 months follow-up in accordance with the inclusion criteria.
Predictor Variables:
Type of graft used (iliac crest graft/rhBMP-2/rhBMP-2 with zygoma shaving).
Outcome Variables:
Duration of the operation, blood loss, postoperative drugs used, donor site morbidity, efficiency of bone deposition (radiologically) at 4 months.
Statistics:
Descriptive statistics, one-way ANOVA. P < 0.05 was taken as significant.
Results:
Forty two cases met the inclusion criteria. Mean efficiency of bone deposition was 89.97 ± 4.79%. Mean efficiency of bone formation in rhBMP-2 (n=13), rhBMP-2 with zygoma shavings (n=9) and iliac crest graft (n=20) was 89.42%, 95.38% and 87.91%, respectively (P=0.000). Drugs usage and postoperative morbidity differed significantly between groups (P < 0.05).
Conclusion:
The use of rhBMP-2 evades the need for additional surgery and overcomes the postoperative morbidity that is associated with the conventional iliac grafting technique. The rhBMP-2 with zygoma shavings showed maximum benefits.
