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Exclusive electron intraoperative radiotherapy in early-stage breast cancer: a monoinstitutional experience
Mattia Falchetto Osti1, Alessia Carnevale, Stefano Bracci
1Sant'Andrea Hospital, Department of Radiation Oncology, Via di Grottarossa 1035, 00189 Roma, Italy.
Aim:
To evaluate the effectiveness of intra-operative radiotherapy (IORT) in breast cancer in terms of local control, esthetic results and disease-free survival.
Patients And Methods:
From June 2007 to October 2011, 110 patients with early-stage breast cancer were submitted to quadrantectomy and IORT. A total dose of 21 Gy prescribed at 90-100% isodose was delivered in all cases. Patients were evaluated after surgery for early and late complications.
Results:
Median follow-up was 27 (range: 2-54) months. In 10 patients (9.1%), breast ultrasound showed liponecrosis. Six patients (5.5%) developed grade 2 fibrosis. Disease-free survival rates at 2 and 3 years were 96.8% and 92.9 %. Three patients (2.7%) developed local recurrence, two patients (1.8%) distant metastasis. Two patients died. The 2- and 3-year overall survival rates were 100% and 97.3%, respectively.
Conclusion:
IORT could be an appropriate therapeutic alternative in selected patients although it remains investigational; longer follow-up to confirm these results is required.
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