Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Bone Disorders

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...

What is the Skeletal System?

What is the Skeletal System?

Osteoclasts in Bone Remodeling

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...

Atypical Pneumonia

Atypical Pneumonia

Atypical pneumonia, often caused by Mycoplasma pneumoniae, is a form of pulmonary infection that differs from the classical presentation of bacterial pneumonia in both its cause and clinical symptoms. Mycoplasma pneumoniae is a pleomorphic bacterium notable for its lack of a rigid cell wall. This structural characteristic imparts resistance to beta-lactam antibiotics and significantly influences the bacterium’s behavior within the human host.Other pathogens responsible for the disease include...

Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications

Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications

Peritoneal dialysis (PD) is a medical process that removes waste products and excess fluid from the body using the peritoneal membrane as a natural filter.Peritoneal Dialysis MethodsSeveral methods can be used for peritoneal dialysis, including Acute Intermittent Peritoneal Dialysis, Continuous Ambulatory Peritoneal Dialysis, and Automated Peritoneal Dialysis, also known as Continuous Cyclic Peritoneal Dialysis.Acute Intermittent Peritoneal Dialysis (AIPD) is used for patients with uremic...

Skin Diseases and Disorders

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Rational Prescribing Under Pressure: A World Health Organization Indicator and National Medical Commission Compliance Audit With Shift-Based Analysis of Emergency Prescriptions at a Tertiary Care Hospital in North India.

Cureus·2026

Same author

Diagnostic Utility of Cytology and Cell Block with Immunohistochemistry in Detection of Peritoneal Metastasis in Gynecological Malignancies.

Journal of cytology·2026

Same author

Electrolyte-engineering for enhanced charge storage in Ni metal-organic framework electrodes for high performance supercapacitors.

RSC advances·2026

Same author

Chronic kidney disease in cirrhosis: a study of inpatients from a global perspective.

Gut·2026

Same author

Exploring role of therapeutic plasma exchange for hepatitis A-related acute liver failure: An Indian multi-center cohort study.

Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology·2026

Same author

Correlation of Levels of Placental Growth Factor and Soluble FMS-Like Tyrosine Kinase with Severity and Prognosis of Preeclampsia-Eclampsia Syndrome.

Journal of obstetrics and gynaecology of India·2026

Search research articles

Related Experiment Videos

Osteopetrosis-A rare entity with osteomyelitis.

R S Bedi¹, Poonam Goel, Navbir Pasricha

¹Department of Oral and Maxillofacial Surgery, Saraswati Dental College and Hospital, Lucknow, Uttar Pradesh, India.

Annals of Maxillofacial Surgery

|March 14, 2013

Summary

Osteopetrosis, a rare genetic bone disorder, can lead to complications like osteomyelitis. This case report highlights osteomyelitis in an 8-year-old boy with osteopetrosis, emphasizing bone remodeling defects.

Keywords:

Osteomyelitis osteopetrosis osteosclerosis

Related Experiment Videos

Area of Science:

Medical Genetics
Orthopedics
Pediatrics

Background:

Osteopetrosis is a rare genetic disorder characterized by impaired bone resorption and remodeling, leading to generalized bone sclerosis.
Albers-Schönberg disease, or autosomal dominant osteopetrosis type II, is a specific, rare subtype of this condition.
Osteomyelitis is a known complication in patients with osteopetrosis.

Observation:

This case report details an 8-year-old boy diagnosed with osteopetrosis.
The patient presented with osteomyelitis, a significant complication of the underlying bone disorder.
Dental abnormalities were also noted, potentially linked to defective bone remodeling processes.

Findings:

The case illustrates the occurrence of osteomyelitis as a complication in pediatric osteopetrosis.
Pathological changes in bone remodeling associated with osteopetrosis may contribute to complications like osteomyelitis and dental issues.
This presentation underscores the challenges in managing patients with rare bone diseases.

Implications:

Early recognition and management of complications like osteomyelitis are crucial in pediatric osteopetrosis.
Understanding the link between bone remodeling defects and secondary infections is important for clinical practice.
Further research into the management of osteopetrosis complications may improve patient outcomes.