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Updated: May 13, 2026

Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay
Published on: November 10, 2013
Non-classical anticancer agents: on the way to water soluble zinc(II) heteroleptic complexes
Barbara Sanz Mendiguchia1, Daniela Pucci, Teresa F Mastropietro
1Centro di Eccellenza CEMIF.CAL, LASCAMM CR-INSTM and Laboratorio Regionale Licryl, CNR-INFM, Dipartimento di Chimica, Università della Calabria, 87030 Arcavacata di Rende (CS), Italy.
Abstract:
Two new heteroleptic Zn(II) complexes of the 4,4'-bis(hydroxymethyl)-2,2'-bipyridine have been synthesized by using different stoichiometric ratios of tropolone. In an attempt to induce the formation of metal complex co-crystals, liquid assisted solid state reaction followed by solvent crystallization has been conducted by using the new Zn(II) tropolonate derivatives 1 and 2 with saccharin. The novel Zn(II) species obtained exhibits different structures and properties with respect to their precursors, due to a hydrogen exchange between saccharin and the tropolonate coordinated ligand.
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