Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Gastritis II: Pathophysiology

Gastritis II: Pathophysiology

The pathophysiology of gastritis begins with the colonization of the stomach lining by Helicobacter pylori (H. pylori). This bacterium spreads mainly via the oral-oral route through saliva or shared utensils, and can also be transmitted in overcrowded or unhygienic environments through contaminated water, despite its brief survival outside the body.ColonizationOnce ingested, H. pylori enters the stomach and begins colonization by navigating through the mucus layer lining the stomach wall. It...

Abnormal Proliferation

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...

Mitogens and the Cell Cycle

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Polariton manipulation <i>via</i> boundary engineering.

Nanoscale·2026

Same author

A telomere-to-telomere gapfree genome assembly of Triplophysa stoliczkae (Tibetan stone loach, family Nemacheilidae).

Scientific data·2026

Same author

Domain-Targeted RNAi of VeA Reveals Its Essential Role in the Fusarium oxysporum-Pseudostellaria heterophylla Interaction.

Molecular plant pathology·2026

Same author

Chaperonin in health and disease.

Molecular biomedicine·2026

Same author

CCT5 maintains mitotic fidelity and promotes early colorectal tumorigenesis.

iScience·2026

Same author

The role of autophagy in microwave radiation induced toxicity in iPSC-derived cardiomyocytes.

Current research in toxicology·2026

Search research articles

Related Experiment Video

Updated: May 13, 2026

Development of Compendium for Esophageal Squamous Cell Carcinoma

Development of Compendium for Esophageal Squamous Cell Carcinoma

Published on: April 12, 2024

Selenium-binding protein 1 may decrease gastric cellular proliferation and migration.

Chenjing Zhang¹, Wen Xu, Wensheng Pan

¹Department of Gastroenterology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, PR China.

International Journal of Oncology

|March 14, 2013

Summary

Selenium-binding protein 1 (SBP1) suppression promotes gastric cancer growth and reduces chemotherapy effectiveness. SBP1 overexpression inhibits cancer progression, suggesting it as a therapeutic target for gastric cancer.

More Related Videos

An Immunofluorescent Method for Characterization of Barrett’s Esophagus Cells

An Immunofluorescent Method for Characterization of Barrett’s Esophagus Cells

Published on: July 20, 2014

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer

Published on: September 18, 2020

Related Experiment Videos

Last Updated: May 13, 2026

Development of Compendium for Esophageal Squamous Cell Carcinoma

Development of Compendium for Esophageal Squamous Cell Carcinoma

Published on: April 12, 2024

An Immunofluorescent Method for Characterization of Barrett’s Esophagus Cells

An Immunofluorescent Method for Characterization of Barrett’s Esophagus Cells

Published on: July 20, 2014

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer

Published on: September 18, 2020

Area of Science:

Oncology
Molecular Biology
Biochemistry

Background:

Selenium-binding protein 1 (SBP1) is frequently suppressed in human malignancies.
The precise function and regulatory mechanisms of SBP1 in cancer remain largely unknown.
SBP1 is implicated in cancer development and progression.

Purpose of the Study:

To investigate the role of SBP1 in gastric cancer cell proliferation, migration, senescence, and chemoresistance.
To evaluate the impact of SBP1 expression levels on gastric cancer cell behavior and response to cisplatin.
To determine if SBP1 can serve as a potential therapeutic target for gastric cancer.

Main Methods:

Cell proliferation assays were performed on gastric cancer cell lines (SGC7901 and BGC823).
Immunochemical staining and immunoblotting were used to assess SBP1 expression.
Flow cytometry analyzed apoptosis and cell cycle.
A xenograft model was utilized to evaluate SBP1's in vivo effects.

Main Results:

Diminished SBP1 expression enhanced gastric cancer cell proliferation and migration.
Reduced SBP1 levels decreased cisplatin-induced apoptosis in gastric cancer cells.
Overexpression of SBP1 exhibited opposing effects, inhibiting proliferation and migration while enhancing chemoresistance.

Conclusions:

SBP1 plays a significant role in regulating gastric cancer cell proliferation and migration.
SBP1 modulates the sensitivity of gastric cancer cells to anticancer drugs like cisplatin.
SBP1 represents a promising therapeutic target for suppressing gastric cancer progression.