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Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...
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Double Emulsion Generation Using a Polydimethylsiloxane (PDMS) Co-axial Flow Focus Device
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Published on: December 25, 2015

Multiple emulsions controlled by stimuli-responsive polymers.

Lucie Besnard1, Frédéric Marchal, Jose F Paredes

  • 1DSM, IRAMIS, UMR 3299 CEA/CNRS SIS2M, Laboratoire Interdisciplinaire sur l'Organisation Nanométrique et Supramoléculaire (LIONS), C.E.A. Saclay, Gif sur Yvette cedex, France.

Advanced Materials (Deerfield Beach, Fla.)
|March 14, 2013
PubMed
Summary
This summary is machine-generated.

Phase inversion in emulsions involves multiple emulsion formation. A copolymer stabilizer causes oil-in-water emulsions to become water-in-oil emulsions via stable multiple emulsions at specific pH and temperature conditions.

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Area of Science:

  • Colloid and Surface Science
  • Polymer Chemistry
  • Materials Science

Background:

  • Emulsion stability is crucial in various industrial applications.
  • Thermo- and pH-sensitive polymers offer tunable properties for emulsion stabilization.
  • Understanding phase inversion mechanisms is key to controlling emulsion characteristics.

Purpose of the Study:

  • To investigate the phase inversion mechanism of water-toluene emulsions.
  • To determine the role of a thermo- and pH-sensitive copolymer in emulsion stabilization and phase inversion.
  • To characterize the types of emulsions formed at different pH and temperature conditions.

Main Methods:

  • Preparation of water-toluene emulsions stabilized by a thermo- and pH-sensitive copolymer.
  • Systematic variation of pH and temperature to induce phase inversion.
  • Microscopic observation and stability analysis of the resulting emulsions.

Main Results:

  • Phase inversion occurs through the formation of multiple emulsions.
  • At low pH and ambient temperature, oil-in-water emulsions are observed.
  • Highly stable multiple emulsions form just below the inversion pH, transitioning to water-in-oil emulsions at higher pH.

Conclusions:

  • The thermo- and pH-sensitive copolymer effectively stabilizes emulsions and controls phase inversion.
  • Multiple emulsion formation is a key intermediate step in the phase inversion process.
  • The study provides insights into designing responsive emulsion systems for tailored applications.