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Updated: May 13, 2026

A Protocol for Constructing a Rat Wound Model of Type 1 Diabetes
Published on: February 17, 2023
Abnormal cell responses and role of TNF-α in impaired diabetic wound healing
Fanxing Xu1, Chenying Zhang, Dana T Graves
1School of Life Science and Biotechnology, Dalian University of Technology, Dalian 116024, China.
Abstract:
Impaired diabetic wound healing constitutes a major health problem. The impaired healing is caused by complex factors such as abnormal keratinocyte and fibroblast migration, proliferation, differentiation, and apoptosis, abnormal macrophage polarization, impaired recruitment of mesenchymal stem cells (MSCs) and endothelial progenitor cells (EPCs), and decreased vascularization. Diabetes-enhanced and prolonged expression of TNF- α also contributes to impaired healing. In this paper, we discuss the abnormal cell responses in diabetic wound healing and the contribution of TNF- α .
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