Related Experiment Video
Updated: May 13, 2026

Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials
Published on: August 13, 2019
Long-term effect on tooth vitality of regenerative therapy in deep periodontal bony defects: a retrospective study
Massimo de Sanctis1, Cecilia Goracci, Giovanni Zucchelli
1Department of Periodontology, Siena University, Siena, Italy. massimodesanctis@tin.it
Abstract:
Over the last few decades, many authors have investigated the effect of periodontal disease and treatment on pulpal status with controversial results. This study was conducted to verify whether periodontal disease in a deep intrabony defect and complex therapy, including aggressive root planing such as in periodontal regeneration, have an influence on tooth vitality. One hundred thirty-seven patients who fulfilled the requirements were included. The collected data did not support the need for "preventive" root canal treatment in severely compromised teeth that are planned to undergo periodontal regenerative surgery.