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Forward Genetics Screens Using Macrophages to Identify Toxoplasma gondii Genes Important for Resistance to IFN-γ-Dependent Cell Autonomous Immunity
Published on: March 12, 2015
[Research progress on invasion mechanism and immunology of Toxoplasma gondii]
1State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China.
Abstract:
Toxoplasma gondii is a kind of obligate intracellular parasite and causes serious harm to human health and the development of animal husbandry. Recent years, significant research on its mechanism of host-invading and immunology has been conducted, and considerable research progress has been made, which are important for an indepth knowledge of pathogenesis of Toxoplasma gondii and immune prevention. This paper reviews the invading process of the parasite in the viewpoint of molecular and cell biology, and the effects of different kinds of immunocytes and the immune responses in the organs.
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