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Updated: May 13, 2026

Quantification of Metal Leaching in Immobilized Metal Affinity Chromatography
Published on: January 17, 2020
[Developments in determination of elements using ICP-MS in blood and urine]
Su-Jing Zhang1, Xian-Yi Zhuo, Dong Ma
1School of Pharmacy, Medical College of Soochow University, Suzhou 215123, China.
Inductively coupled plasma-mass spectrometry (ICP-MS) is a key technique for multi-element analysis in biological samples like blood and urine. This review covers sample preparation, interference correction, and factors influencing results for forensic toxicology applications.
Area of Science:
- Analytical Chemistry
- Forensic Science
Context:
- Inductively coupled plasma-mass spectrometry (ICP-MS) is the predominant method for elemental analysis.
- Its high sensitivity and broad linear range are suitable for multi-element analysis in biological matrices such as blood and urine.
Purpose:
- To review common sample pretreatment methods (direct dilution and wet digestion).
- To discuss techniques for correcting mass spectral interferences.
- To provide an outlook on ICP-MS applications in forensic toxicology.
Summary:
- This paper details ICP-MS techniques for elemental analysis in biological samples.
- It covers sample preparation, interference correction, and key factors affecting results.
- The review focuses on the utility of ICP-MS in forensic toxicological analysis.
Impact:
- Enhances understanding of ICP-MS for accurate elemental quantification in forensic toxicology.
- Provides a comprehensive overview of critical method parameters for researchers and practitioners.
- Facilitates the application of advanced analytical techniques in forensic investigations.
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