[Actinic keratosis: the art of doing nothing]

Just A H Eekhof1

  • 1Gezondheidscentrum Stevenshof, Leiden, the Netherlands. j.eekhof@nhg.org

Insights

General practitioners often assess skin lesions like actinic keratoses. Watchful waiting is a justifiable approach for non-malignant, asymptomatic actinic keratoses, especially in elderly patients.

Area of Science:

  • Dermatology
  • Oncology

Context:

  • General practitioners frequently encounter diverse skin lesions in clinical practice.
  • Actinic keratoses (AKs) are common precancerous skin lesions, particularly in the elderly population.
  • Distinguishing between benign AKs and invasive squamous cell carcinoma is a clinical challenge.

Purpose:

  • To provide guidance on the management of actinic keratoses.
  • To clarify when watchful waiting is an appropriate strategy for actinic keratoses.
  • To inform general practitioners about therapeutic guidelines for precancerous skin lesions.

Summary:

  • Actinic keratoses are precancerous lesions that can progress to squamous cell carcinoma.
  • Therapeutic guidelines exist for managing actinic keratoses.
  • Watchful waiting is a justifiable option for small, non-malignant, asymptomatic actinic keratoses not presenting as a chief complaint.

Impact:

  • Supports evidence-based decision-making for general practitioners managing actinic keratoses.
  • Aims to reduce unnecessary treatments for benign skin conditions.
  • Contributes to the appropriate management of precancerous skin lesions, potentially preventing invasive cancer.

Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Cells of the Epidermis01:24

Cells of the Epidermis

The epidermis is made of four or five layers of epithelial cells, depending on its location in the body. From deep to superficial, these layers are the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum.
The cells in all these layers except the stratum basale are called keratinocytes, a type of cell that manufactures and stores the protein keratin. The keratinocytes in the stratum corneum are dead and regularly slough away, being replaced by cells from...
Accessory Structures of the Skin: Hair Growth and Types01:20

Accessory Structures of the Skin: Hair Growth and Types

Hair growth begins with the production of keratinocytes by the basal cells of the hair bulb. As new cells are deposited at the hair bulb, the hair shaft is pushed through the follicle toward the surface. Keratinization is completed as the cells are pushed to the skin surface to form the shaft of hair that is externally visible. The external hair is completely dead and composed entirely of keratin. Hair can be cut or shaven without damaging the hair structure because the cut is superficial. Most...
Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular cells,...
Pigmentation01:19

Pigmentation

The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...