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Related Experiment Video

Updated: May 13, 2026

A Microfluidic Device for Studying Multiple Distinct Strains
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A Microfluidic Device for Studying Multiple Distinct Strains

Published on: November 9, 2012

Microplates based on liquid bridges between glass rods.

Brandon Huey-Ping Cheong1, Jonathan Kok Keung Lye, Scott Backhous

  • 1Laboratory for Optics, Acoustics, & Mechanics, Department of Mechanical & Aerospace Engineering, Monash University, Clayton, Victoria 3800, Australia.

Journal of Colloid and Interface Science
|March 15, 2013
PubMed
Summary

This study introduces a novel microplating method using capillary-held liquid bridges for simple, precise liquid handling and fluorescent diagnostics. This technique enables efficient mixing and accurate measurements, paving the way for lab-on-a-chip devices.

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Area of Science:

  • Biotechnology
  • Microfluidics
  • Analytical Chemistry

Background:

  • Traditional microplating methods often require complex machinery for precise liquid dispensing.
  • There is a need for microfluidic systems that facilitate fluorescent optical diagnosis and simple mechanical analyte mixing.

Purpose of the Study:

  • To develop a novel microplating technique that overcomes limitations of existing methods.
  • To enable precise liquid handling, fluorescent measurements, and efficient mixing using capillary forces.

Main Methods:

  • A new approach utilizing liquid bridges formed by capillary forces between parallel glass rods was developed.
  • Liquid filling characteristics were experimentally investigated and analytically modeled.
  • Mechanical mixing was achieved through cyclical translation and reattachment of liquid bridges.

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The Preparation of Electrohydrodynamic Bridges from Polar Dielectric Liquids
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The Preparation of Electrohydrodynamic Bridges from Polar Dielectric Liquids

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The Preparation of Electrohydrodynamic Bridges from Polar Dielectric Liquids
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  • Fluorescence signals were measured relative to EGFP concentration using standard and optical fiber illumination.

    • Main Results:

    • Experimental results confirmed theoretical predictions for liquid filling.
    • Analytical models identified regions of minimal uncertainty in liquid body cross-sectional area, ensuring consistent fluorescence measurements.
    • Cyclical rod translation effectively mixed analytes.
    • Strong linear correlations were observed between fluorescence signals and EGFP concentration.

    Conclusions:

    • The novel capillary-based microplating method offers a simple, precise, and efficient alternative for liquid handling and analysis.
    • The technique's compatibility with fluorescent detection and mechanical mixing supports its potential for integrated lab-on-a-chip device development.