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Expert Opinion on Drug Discovery

|March 15, 2013

Summary

Drug discovery for psychiatric disorders faces challenges, but cognitive dysfunction is a key target. Functional magnetic resonance imaging (fMRI) shows promise for developing novel treatments for neuropsychiatric conditions.

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Area of Science:

Neuroscience
Psychiatry
Pharmacology

Background:

Psychiatric drug discovery faces significant challenges, hindering progress in treating serious mental illnesses.
Cognitive dysfunction is a critical, yet largely untreated, symptom that predicts clinical outcomes in neuropsychiatric disorders.

Purpose of the Study:

To explore the potential of non-invasive functional neuroimaging, specifically functional magnetic resonance imaging (fMRI), for investigating cognitive dysfunction.
To examine the application of fMRI in assessing novel agents targeting cognitive deficits in schizophrenia.

Main Methods:

Utilizing functional magnetic resonance imaging (fMRI) as a primary tool to investigate cognitive dysfunction.
Applying fMRI to study the effects of pharmacological agents on cognition in neuropsychiatric conditions, exemplified by schizophrenia.

Main Results:

Functional magnetic resonance imaging (fMRI) offers advantages over other methodologies for studying cognitive function.
Identified both benefits and challenges in applying fMRI technology for drug development in psychiatry.

Conclusions:

Pharmaco-fMRI is an emerging and powerful tool for enhancing the drug development process in psychiatry.
This approach holds promise for delivering novel treatments for patients with diverse neuropsychiatric disorders.