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Related Concept Videos

Drug Discovery: Overview01:26

Drug Discovery: Overview

Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
Protein Glycosylation01:25

Protein Glycosylation

Glycosylation, the most common post-translational modification for proteins, serves diverse functions. Adding sugars to proteins makes the proteins more resistant to proteolytic digestion. Glycosylated proteins can act as markers and receptors to promote cell-cell adhesion. Additionally, they have many essential quality control functions in the cell, such as correct protein folding and facilitating transport of misfolded proteins to the cytosol, which can be degraded.
Glycosylation occurs in...
Oligosaccharide Assembly01:24

Oligosaccharide Assembly

Protein glycosylation starts in the ER lumen and continues in the Golgi apparatus. Glycosyltransferases catalyze the addition of sugar molecules or glycosylation of proteins. Usually, these enzymes add sugars to the hydroxyl groups of selected serine or threonine residues to form O-linked glycans or the amino groups of asparagine residues to form N-linked glycans. Different positions on the same polypeptide chain can contain differently linked glycans.
Multiple sugar molecules that may or may...

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Bioinformatics Resources for the Study of Glycan-Mediated Protein Interactions
11:21

Bioinformatics Resources for the Study of Glycan-Mediated Protein Interactions

Published on: January 20, 2022

Using glycome databases for drug discovery.

Kiyoko F Aoki-Kinoshita1

  • 1Associate Professor, Department of Bioinformatics, Faculty of Engineering, Soka University, 1-236 Tangi-cho, Hachioji, Tokyo, 192-8577, Japan +81 42 691 4116 ; +81 42 691 4116 ; kkiyoko@soka.ac.jp.

Expert Opinion on Drug Discovery
|March 15, 2013
PubMed
Summary
This summary is machine-generated.

Glycomics databases offer significant potential for drug discovery. This review highlights key resources and suggests integration strategies for efficient research, aiding scientists in navigating these valuable tools.

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Area of Science:

  • Glycomics and Glycobiology
  • Bioinformatics and Cheminformatics

Background:

  • Advancements in glycomics technologies, such as carbohydrate microarrays, have spurred growth in the field.
  • Numerous publicly accessible glycomics databases have been established by major global institutions.

Purpose of the Study:

  • To review and introduce accessible glycomics databases and resources.
  • To identify databases with potential applications in developing novel drug discovery methods.

Main Methods:

  • Systematic review of documented and accessible glycomics databases.
  • Selection of resources based on their utility for drug discovery research.

Main Results:

  • A wide array of glycomics databases with substantial potential for drug discovery applications.
  • The review provides perspective on these resources, mitigating potential overwhelm for researchers.

Conclusions:

  • Glycomics databases represent a valuable, albeit vast, resource for drug discovery.
  • Recommendations are provided for integrating these databases to enhance research efficiency and accelerate the discovery process.