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Lead finding from medicinal plants with hepatoprotective potentials
Pulok K Mukherjee1, Atish K Sahoo, Nisha Narayanan
1Director School of Natural Product Studies, Department of Pharmaceutical Technology, Jadavpur University, Kolkata-700032, India +91 33 2429 8313 ; +91 33 2414 6046 ; pulokm@gmail.com.
Expert Opinion on Drug Discovery
|March 15, 2013
Summary
Natural products show promise for liver protection. This review highlights medicinal plants with proven hepatoprotective effects and their phytochemical profiles for therapeutic benefits.
Area of Science:
- Pharmacology
- Phytochemistry
- Hepatology
Background:
- Drug-induced liver injury and toxins pose significant health risks.
- Natural products, particularly herbs, have a long history of use in treating liver disorders.
- Hepatoprotective compounds derived from natural sources are crucial for managing liver diseases.
Purpose of the Study:
- To review medicinal plants with established hepatoprotective activity.
- To highlight the phytochemical constituents of these plants.
- To identify effective natural leads for liver disease treatment.
Main Methods:
- Literature review of pharmacological studies on medicinal plants.
- Analysis of phytochemical profiles of identified plants.
- Evaluation of traditional and clinical evidence for hepatoprotective effects.
Main Results:
- Several plant species demonstrate significant hepatoprotective effects.
- Key phytochemical compounds responsible for these effects have been identified.
- The review consolidates evidence for natural product efficacy in liver protection.
Conclusions:
- Medicinal plants offer a valuable resource for developing hepatoprotective therapies.
- Understanding phytochemical profiles enhances the therapeutic application of these natural products.
- Further research can leverage these findings for novel liver disease treatments.
