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Large-scale studies to identify biomarkers for heart disease: a role for proteomics?
Shaan Chugh1, Peter Liu, Andrew Emili
1University of Toronto, Department of Physiology, 112 College St, Rm 307, ON, Canada M5G 1L6 +1 416 978 5609 ; +1 416 978 8528 ; anthony.gramolini@utoronto.ca.
Background:
In clinical practice, timely detection of disease and accurate diagnosis are highly important for the effective treatment of various patient populations. Biomarkers offer a new and innovative means of assessing the disease state during early, mid and late stages of progression.
Objective:
Advancements in various proteomic platforms used to study the disease proteome and their applications to the field of clinical medicine are reviewed.
Methods:
A literature review was done to study proteomic technology and its contribution to the discovery of cardiac biomarkers.
Conclusion:
Proteomic profiling experiments can allow for the establishment of cardiac biomarkers, which can often offer information regarding the severity of the disease state. As high-throughput evaluation of various cardiac disease proteomes continues to improve in precision, the prospect of offering medical treatment that is tailored to the individual could follow.
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