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Induction of Experimental Autoimmune Hypophysitis in SJL Mice
Published on: December 17, 2010
Lymphocytic hypophysitis in males
Akshay Hindocha1, B Roy Chaudhary, Tara Kearney
1Department of Neurosurgery, Greater Manchester Neurosciences Centre, Salford Royal Foundation Trust, Salford Royal Hospital, Stott Lane, Salford, Manchester M6 8HD, UK.
Summary
Lymphocytic hypophysitis (LH), a rare pituitary inflammation, can occur in men, presenting with headaches and vision loss. Diagnosis in males requires considering LH for pituitary masses and hypopituitarism.
Area of Science:
- Endocrinology
- Neurology
- Pathology
Background:
- Lymphocytic hypophysitis (LH) is a rare inflammatory pituitary gland disorder.
- It predominantly affects women during the peripartum period.
Observation:
- This report details two male patients (43 and 36 years old) presenting with headaches, visual disturbances, and hypopituitarism.
- Magnetic Resonance Imaging (MRI) revealed heterogeneous pituitary lesions extending into the suprasellar region with a thickened pituitary stalk.
Findings:
- Histopathological diagnosis confirmed Lymphocytic Hypophysitis (LH) in both male patients post-endoscopic transsphenoidal surgery.
- This confirms LH can manifest in males, distinct from its typical demographic.
Implications:
- Male Lymphocytic Hypophysitis (LH) should be considered in the differential diagnosis for men presenting with hypopituitarism.
- Heterogeneous pituitary fossa masses with suprasellar extension and pituitary stalk thickening in males warrant investigation for LH.
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