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Related Experiment Video

Updated: May 13, 2026

Induction of Experimental Autoimmune Hypophysitis in SJL Mice

Induction of Experimental Autoimmune Hypophysitis in SJL Mice

Published on: December 17, 2010

Lymphocytic hypophysitis in males.

Akshay Hindocha¹, B Roy Chaudhary, Tara Kearney

¹Department of Neurosurgery, Greater Manchester Neurosciences Centre, Salford Royal Foundation Trust, Salford Royal Hospital, Stott Lane, Salford, Manchester M6 8HD, UK.

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia

|March 15, 2013

Summary

This summary is machine-generated.

Lymphocytic hypophysitis (LH), a rare pituitary inflammation, can occur in men, presenting with headaches and vision loss. Diagnosis in males requires considering LH for pituitary masses and hypopituitarism.

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Area of Science:

Endocrinology
Neurology
Pathology

Background:

Lymphocytic hypophysitis (LH) is a rare inflammatory pituitary gland disorder.
It predominantly affects women during the peripartum period.

Observation:

This report details two male patients (43 and 36 years old) presenting with headaches, visual disturbances, and hypopituitarism.
Magnetic Resonance Imaging (MRI) revealed heterogeneous pituitary lesions extending into the suprasellar region with a thickened pituitary stalk.

Findings:

Histopathological diagnosis confirmed Lymphocytic Hypophysitis (LH) in both male patients post-endoscopic transsphenoidal surgery.
This confirms LH can manifest in males, distinct from its typical demographic.

Implications:

Male Lymphocytic Hypophysitis (LH) should be considered in the differential diagnosis for men presenting with hypopituitarism.
Heterogeneous pituitary fossa masses with suprasellar extension and pituitary stalk thickening in males warrant investigation for LH.