Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Chronic Bowel Disorders: Introduction

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...

Cholecystitis

Cholecystitis

Cholecystitis is inflammation of the gallbladder, most commonly caused by obstruction of the cystic duct. This blockage prevents bile from draining, leading to gallbladder distension, inflammation, and potentially serious complications. This condition may present acutely or chronically and can happen with or without gallstones.EtiologyAbout 95% of cholecystitis cases are calculous, caused by gallstones blocking the cystic duct, leading to bile accumulation and inflammation of the gallbladder...

Inflammatory Bowel Disease I: Ulcerative Colitis

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Air emissions from the shipbuilding process.

Marine pollution bulletin·2025

Same author

Hepatic presentations of mitochondrial DNA depletion syndrome in children: A single tertiary liver centre experience.

Journal of inherited metabolic disease·2023

Same author

Sooner than you think: A very early affective reaction to the COVID-19 pandemic and quarantine in Argentina.

Journal of affective disorders·2021

Same author

Assessing DNA methylation in the developing human intestinal epithelium: potential link to inflammatory bowel disease.

Mucosal immunology·2015

Same author

ESPGHAN position paper on management of percutaneous endoscopic gastrostomy in children and adolescents.

Journal of pediatric gastroenterology and nutrition·2014

Same author

Hepatopathy of Mauriac syndrome: a retrospective review from a tertiary liver centre.

Archives of disease in childhood·2014

Search research articles

Related Experiment Video

Updated: May 13, 2026

Laparoscopic Choledochal Cyst Excision and Roux-en-Y Choledochojejunostomy in Adults

Laparoscopic Choledochal Cyst Excision and Roux-en-Y Choledochojejunostomy in Adults

Published on: February 28, 2025

Colitis-associated sclerosing cholangitis in children: a single centre experience.

G Noble-Jamieson¹, R B Heuschkel, F Torrente

¹Department of Paediatric Gastroenterology, Addenbrooke's Hospital, Cambridge University, UK.

Journal of Crohn'S & Colitis

|March 15, 2013

Summary

Pediatric inflammatory bowel disease (IBD) patients with abnormal liver tests show a higher prevalence of hepato-biliary disease than previously thought. Early diagnosis via liver biopsy and cholangiography is recommended for better management.

Keywords:

Auto-immune liver disease Hepato-biliary disease;Inflammatory bowel disease;Sclerosing cholangitis;Ulcerative colitis;

Related Experiment Videos

Last Updated: May 13, 2026

Laparoscopic Choledochal Cyst Excision and Roux-en-Y Choledochojejunostomy in Adults

Laparoscopic Choledochal Cyst Excision and Roux-en-Y Choledochojejunostomy in Adults

Published on: February 28, 2025

Area of Science:

Hepatology
Gastroenterology
Pediatric IBD

Background:

Sclerosing cholangitis (SC) is an immune-mediated manifestation of inflammatory bowel disease (IBD), primarily ulcerative colitis (UC).
Reported prevalence of SC in pediatric UC patients is low (2-7%).
This study investigates hepatological findings in children with inflammatory colitis and elevated liver function tests (LFTs).

Purpose of the Study:

To determine the prevalence of hepato-biliary disease in children with inflammatory colitis and abnormal LFTs.
To highlight the importance of early diagnosis and management of IBD-associated hepato-biliary disease in pediatric patients.

Main Methods:

Retrospective review of medical records.
Study included 17 children and adolescents with inflammatory colitis and abnormal LFTs.
Procedures included liver biopsy and cholangiography.

Main Results:

17 out of 52 patients (32.6%) with inflammatory colitis had abnormal LFTs.
All 17 patients with abnormal LFTs were diagnosed with hepato-biliary disease.
This represents a higher prevalence than previously reported in pediatric IBD.

Conclusions:

The prevalence of IBD-associated hepato-biliary disease in children with abnormal LFTs is significantly higher than previously reported.
Diagnosis impacts patient management.
Recommend liver biopsy and cholangiography for all children with inflammatory colitis and abnormal LFTs.