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[Cefpiramide: antibacterial activity, pharmacokinetics, and clinical evaluation]
Abstract:
We determined MIC values of cefpiramide (CPM) against clinical isolates from 100 patients who were subjected to total hysterectomy between April 1986 and March 1988. We also investigated the concentrations of CPM in uterine tissue and assessed the clinical efficacy of postoperative prophylaxis. 1. Against bacteria isolated from clinical materials the MIC80 values of CPM were as follows: Staphylococcus epidermidis 1.56 micrograms/ml, Enterococcus faecalis 25 micrograms/ml, and Escherichia coli 6.25 micrograms/ml. 2. Peak concentrations of CPM in various tissues and tissue/serum ratios of AUC were as follows: cervix uteri 35 micrograms/g (39.5%), perimetrium 43 micrograms/g (44.9%), endometrium 39 micrograms/g (51.6%), myometrium 28 micrograms/g (26.8%), oviduct 67 micrograms/g (41.9%), and ovary 27 micrograms/g (45.8%). In all tissues examined CPM concentrations were above 4 micrograms/g after 600 minutes. 3. Serum half-lives were T 1/2(alpha) = 13.2 minutes and T 1/2(beta) = 260.2 minutes. 4. The efficacy rate in postoperative prophylaxis was 97.9%. 5. No serious side effects were observed.
Insights
Cefpiramide (CPM) demonstrated effective Minimum Inhibitory Concentrations (MICs) against common bacteria and achieved significant concentrations in uterine tissues. Postoperative prophylaxis with CPM showed a high efficacy rate of 97.9% with no serious side effects.
Area of Science:
- Pharmacology
- Microbiology
- Gynecology
Context:
- Study conducted on 100 patients undergoing total hysterectomy between April 1986 and March 1988.
- Evaluated cefpiramide (CPM) against clinical bacterial isolates.
- Assessed CPM concentrations in uterine tissues and its efficacy in postoperative prophylaxis.
Purpose:
- Determine MIC values of cefpiramide against clinical isolates.
- Investigate cefpiramide concentrations within uterine tissues.
- Evaluate the clinical efficacy of cefpiramide for postoperative prophylaxis.
Summary:
- MIC80 values for cefpiramide were: Staphylococcus epidermidis 1.56 µg/mL, Enterococcus faecalis 25 µg/mL, and Escherichia coli 6.25 µg/mL.
- Peak cefpiramide concentrations in uterine tissues ranged from 28-67 µg/g, with tissue/serum AUC ratios between 26.8%-51.6%.
- Serum half-lives were T 1/2(alpha) = 13.2 min and T 1/2(beta) = 260.2 min, with concentrations above 4 µg/g in tissues after 600 minutes.
Impact:
- Cefpiramide demonstrated significant antibacterial activity and favorable tissue penetration in gynecological tissues.
- Achieved a high clinical efficacy rate of 97.9% in postoperative prophylaxis.
- No serious adverse effects were reported, indicating a favorable safety profile.