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Behavioral changes in Egyptian children with nephrotic syndrome

Emad Emil Ghobrial1, Sameh Samir Fahmey, Maha Emad Eldin Ahmed

  • 1Department of Pediatrics, New Children's Hospital, Faculty of Medicine, Cairo University, Cairo, Egypt. emadoozi@yahoo.com

Iranian Journal of Kidney Diseases
|March 15, 2013
PubMed

Insights

Children with steroid-resistant nephrotic syndrome (SRNS) may experience more behavioral issues. Early attention to psychological problems in children with nephrotic syndrome (NS) is recommended.

Area of Science:

  • Pediatric Nephrology
  • Child Psychology
  • Behavioral Science

Background:

  • Chronic illnesses like nephrotic syndrome (NS) are linked to psychosocial stress.
  • Understanding psychological challenges in children with NS is crucial for comprehensive care.

Purpose of the Study:

  • To assess and compare psychological problems in children with different forms of nephrotic syndrome (NS).
  • To identify potential behavioral differences between steroid-sensitive NS (SSNS), steroid-dependent NS (SDNS), and steroid-resistant NS (SRNS).

Main Methods:

  • Sixty children diagnosed with NS were evaluated for behavioral changes using the Arabic version of the Strength and Difficulties Questionnaire.
  • Participants were categorized into three groups based on their NS treatment status: SSNS, SDNS, and SRNS.
  • Results were compared across the three groups to identify significant differences in psychological and behavioral scores.

Main Results:

  • The study included 20 children in each of the SSNS, SDNS, and SRNS groups, aged 4-16 years.
  • The SRNS group showed significant differences in clinical parameters including age of onset, serum protein/albumin/calcium, GFR, urine protein, BUN, and cholesterol.
  • While not statistically significant, the SRNS group exhibited higher scores for emotional symptoms, peer problems, and overall difficulties, along with lower prosocial scores compared to other groups.

Conclusions:

  • Children with steroid-resistant nephrotic syndrome (SRNS) may be more prone to emotional symptoms, conduct problems, peer relationship difficulties, and hyperactivity.
  • Behavioral and psychological assessments should be integrated early in the management of children with nephrotic syndrome (NS).
  • Further research with larger sample sizes may be needed to confirm the statistical significance of observed behavioral differences in SRNS.
Abstract

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