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Prevalence and risk factors of valvular calcification in hemodialysis patients

Hayriye Sayarlioglu1, Gurkan Acar, Murat Sahin

  • 1Department of Internal Medicine, Division of Nephrology, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey. hayriyesayarlioglu@yahoo.com

Iranian Journal of Kidney Diseases
|March 15, 2013
PubMed

Insights

Heart valve calcification (HVC) affects one-third of hemodialysis patients, particularly older individuals and those with diabetes. HVC is linked to reduced ejection fraction and increased left ventricle mass, but not calcium-phosphorus levels.

Area of Science:

  • Nephrology
  • Cardiology
  • Echocardiography

Background:

  • Valvular abnormalities are common in chronic kidney failure patients.
  • This study investigated heart valve calcification (HVC) prevalence in hemodialysis patients.

Purpose of the Study:

  • To determine the prevalence of HVC in hemodialysis patients.
  • To identify factors associated with HVC in this population.

Main Methods:

  • Retrospective review of 129 hemodialysis patient charts.
  • Systematic recording of demographic and laboratory data.
  • Collection of echocardiographic findings including ejection fraction, valve calcification, left ventricle mass, and pulmonary artery pressure.

Main Results:

  • Prevalence of valvular abnormalities was 33.3%, with mitral and aortic valve calcification noted in 23.3% and 21.7% respectively.
  • Patients with HVC were older and had significantly lower ejection fraction and diminished serum albumin levels.
  • Higher left ventricle mass, left ventricle mass index, and pulmonary artery pressure were observed in patients with HVC.

Conclusions:

  • Age and diabetes mellitus are potential risk factors for HVC in hemodialysis patients.
  • HVC may negatively impact cardiac function, indicated by decreased ejection fraction and increased left ventricle mass index.
  • No association was found between HVC and calcium-phosphorus product or parathyroid hormone levels.
Abstract

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