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Stem Cell Therapy for Tissue Regeneration

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...

Mesenchymal Stem Cells

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...

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Related Experiment Video

Updated: May 13, 2026

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots

Published on: May 21, 2013

Stem cell therapy for human cartilage defects: a systematic review.

P Pastides¹, M Chimutengwende-Gordon, N Maffulli

¹University College London Institute of Orthopaedics and Musculoskeletal Sciences, Royal National Orthopaedic Hospital, Stanmore HA7 4LP, United Kingdom. ppastides@hotmail.com

Osteoarthritis and Cartilage

|March 15, 2013

Summary

Stem cell therapy shows promise for cartilage repair in lab studies, but human evidence is limited. More high-quality clinical trials are needed to confirm its effectiveness in treating human cartilage defects.

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Area of Science:

Regenerative Medicine
Orthopedic Surgery
Biomedical Engineering

Background:

Stem cell therapy demonstrates potential for cartilage defect repair based on in vitro and animal research.
Clinical application in human subjects remains under-investigated, with limited published studies.
Systematic review aims to consolidate current human clinical evidence for stem cell therapy in cartilage repair.

Purpose of the Study:

To systematically review existing human studies on stem cell therapy for cartilage defect treatment.
To evaluate the clinical efficacy and application of stem cell therapy in human subjects.
To identify gaps in current research and guide future clinical investigations.

Main Methods:

A comprehensive literature search was conducted following PRISMA guidelines across multiple databases (MEDLINE, EMBASE, Google Scholar, CINHal, SPortDiscus).
An initial retrieval of 105 articles was narrowed down to 11 studies that met the predefined eligibility criteria for the systematic review.
The selected studies form the basis of the review, analyzing their methodologies and findings.

Main Results:

Current evidence supporting the benefits of stem cell therapy for cartilage defects in humans is limited.
Significant heterogeneity exists across studies regarding design, follow-up protocols, and outcome reporting criteria.
The review outlines the variations in methodologies and evaluation criteria employed in the included human trials.

Conclusions:

Further high-quality human clinical trials are essential, given the growing body of preclinical evidence.
The development and implementation of robust, validated reporting methods are crucial for future studies.
More rigorous research is needed to ascertain the true therapeutic effect of stem cell therapy in human cartilage repair.