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Related Concept Videos

Nuclear Magnetic Resonance (NMR): Overview01:07

Nuclear Magnetic Resonance (NMR): Overview

Nuclear magnetic resonance (NMR) is a phenomenon exhibited by certain nuclei that can absorb characteristic radio frequency radiation under certain conditions. NMR has been extensively applied in molecular spectroscopy and medical diagnostic imaging. In both these applications, the molecule or subject under study is placed in a magnetic field and irradiated with radio frequency energy.
NMR spectroscopy generates a spectrum where the characteristic absorption frequencies of the sample are...
Atomic Nuclei: Magnetic Resonance01:05

Atomic Nuclei: Magnetic Resonance

The number of nuclear spins aligned in the lower energy state is slightly greater than those in the higher energy state. In the presence of an external magnetic field, as the spins precess at the Larmor frequency, the excess population results in a net magnetization oriented along the z axis. When a pulse or a short burst of radio waves at the Larmor frequency is applied along the x axis, the coupling of frequencies causes resonance and flips the nuclear spins of the excess population from the...
NMR Spectrometers: Resolution and Error Correction01:14

NMR Spectrometers: Resolution and Error Correction

When magnetic nuclei in a sample achieve resonance and undergo relaxation, the signal detected in NMR is an approximately exponential free induction decay. Fourier transform of an exponential decay yields a Lorentzian peak in the frequency domain. Lorentzian peaks in an NMR spectrum are defined by their amplitude, full width at half maximum, and position, where the peak width is governed by the spin-spin relaxation time alone. In real experiments, however, the applied magnetic field is rendered...
IR Frequency Region: Fingerprint Region01:03

IR Frequency Region: Fingerprint Region

IR spectra are divided into two main regions: the diagnostic region and the fingerprint region. The diagnostic region of the spectrum lies above 1500 cm−1. The absorptions resulting from single-bond vibrations of the N–H, C–H, and O–H stretch at higher wavenumbers and appear on the left side of the spectrum. The stretching absorptions of the C≡C and C≡N occur between 2100–2300 cm−1. In contrast, those arising from stretching absorptions of the C=O, C=N, and C=C occur between 1600–1850 cm−1.
The...
Applications Of NMR In Biology01:25

Applications Of NMR In Biology

Nuclear magnetic resonance (NMR) spectroscopy is a very valuable analytical technique for researchers. It has been used for more than 50 years as an analytical tool. F. Bloch and E. Purcell formulated NMR in 1946 and won the 1952 Nobel Prize in Physics  for their work. Biological macromolecules such as proteins, nucleic acids, lipids, and organic molecules including pharmaceutical compounds, can be studied using this versatile tool that exploits the magnetic properties of certain nuclei.
The...
Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...

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Magnetic Resonance Spectroscopy of live Drosophila melanogaster using Magic Angle Spinning
07:33

Magnetic Resonance Spectroscopy of live Drosophila melanogaster using Magic Angle Spinning

Published on: April 15, 2010

Magnetic resonance fingerprinting.

Dan Ma1, Vikas Gulani, Nicole Seiberlich

  • 1Department of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106, USA.

Nature
|March 15, 2013
PubMed
Summary
This summary is machine-generated.

Magnetic resonance fingerprinting (MRF) enables simultaneous, non-invasive quantification of multiple material or tissue properties. This advanced technique improves accuracy and offers new diagnostic potential for detecting diseases and physical alterations.

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Last Updated: May 12, 2026

Magnetic Resonance Spectroscopy of live Drosophila melanogaster using Magic Angle Spinning
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Area of Science:

  • Medical Imaging
  • Biophysics
  • Materials Science

Background:

  • Magnetic resonance (MR) is a powerful technique, but experiments are largely qualitative.
  • Current MR methods probe only a limited set of material/tissue properties.
  • Existing techniques face limitations in quantitative analysis and error suppression.

Purpose of the Study:

  • Introduce magnetic resonance fingerprinting (MRF) for simultaneous, non-invasive quantification.
  • Enable quantitative analysis of complex changes in materials and tissues.
  • Enhance sensitivity, specificity, and speed of MR studies for diagnostics.

Main Methods:

  • Developed a novel approach for MR data acquisition, post-processing, and visualization.
  • Implemented MR fingerprinting (MRF) for simultaneous property quantification.
  • Utilized pattern-recognition algorithms to improve measurement accuracy.

Main Results:

  • MRF allows non-invasive quantification of multiple material or tissue properties simultaneously.
  • The technique provides a quantitative method to analyze physical alterations or early disease indicators.
  • MRF enhances sensitivity and specificity in identifying target materials or tissues.

Conclusions:

  • MRF offers an alternative to traditional MR, enabling quantitative analysis of complex changes.
  • This method can lead to new diagnostic testing methodologies with improved accuracy.
  • MRF inherently suppresses measurement errors, enhancing overall MR study reliability.