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Updated: May 13, 2026

Green Synthesis of Quinoline-Based Ionic Liquid
Published on: September 27, 2024
Synthesis and antimicrobial activity of novel substituted ethyl 2-(quinolin-4-yl)-propanoates
M Akram Khan1, Keith Miller, Kim Drummond Rainsford
1Biomedical Research Centre, Sheffield Hallam University, Howard Street, Sheffield, S1 1WB, UK. m.a.khan@shu.ac.uk
Abstract:
Substituted 4-hydroxyquinolines were synthesized from anilines and diethyl 2-(ethoxymethylene)malonate by the Gould-Jacobs reaction via cyclization of the intermediate anilinomethylenemalonate followed by hydrolysis and decarboxylation. The 4-hydroxyquinolines reacted with phosphorous oxychloride to form 4-chloroquinolines, which reacted on heating with diethyl sodiomethylmalonate in DMF to yield moderate yields of substituted ethyl 2-(quinolin-4-yl)propanoates, many of which showed potent antimicrobial activity against Helicobacter pylori.
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