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Updated: May 13, 2026

Graphene Coatings for Biomedical Implants
13:21

Graphene Coatings for Biomedical Implants

Published on: March 1, 2013

Graphene coatings for biomedical implants.

Ramakrishna Podila1, Thomas Moore, Frank Alexis

  • 1Department of Physics, Clemson University, USA.

Journal of Visualized Experiments : Jove
|March 15, 2013
PubMed
Summary
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Graphene coatings on nitinol stents improve biological responses and meet functional requirements. This advancement offers a promising alternative to traditional stent materials for enhanced medical applications.

Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Medical Device Engineering

Background:

  • Nitinol alloys are widely used in cardiovascular stents due to their unique properties.
  • Improving the biocompatibility and hemocompatibility of nitinol stents is crucial for reducing complications.
  • Graphene, a 2D nanomaterial, offers potential for surface modification to enhance implant performance.

Purpose of the Study:

  • To develop and evaluate graphene-coated nitinol as a potential stent material.
  • To investigate the impact of graphene coatings on the biological response of vascular cells.
  • To assess the protein adsorption and thrombogenicity of graphene-coated nitinol.

Main Methods:

  • Graphene was synthesized on copper via chemical vapor deposition and transferred to nitinol substrates.

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Preparation and Characterization of Graphene-Based 3D Biohybrid Hydrogel Bioink for Peripheral Neuroengineering
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Last Updated: May 13, 2026

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  • Cell viability, adhesion, and morphology of endothelial and smooth muscle cells were examined.
  • Western blot analysis was used to quantify actin expression.
  • Protein adsorption (albumin, fibrinogen) was analyzed using gel electrophoresis.
  • Raman spectroscopy was employed to study charge transfer from fibrinogen.

    • Main Results:

    • Graphene coatings significantly altered cell adhesion and morphology compared to pristine nitinol.
    • Graphene-coated nitinol demonstrated improved biological responses in cellular assays.
    • Reduced protein adsorption and altered fibrinogen interaction were observed on graphene-coated surfaces.
    • Graphene coating met the functional requirements for stent applications.

    Conclusions:

    • Graphene-coated nitinol exhibits enhanced biocompatibility and hemocompatibility.
    • The developed method provides a viable pathway for creating advanced stent materials.
    • Graphene-coated nitinol is a promising candidate for next-generation cardiovascular stents.