Related Experiment Video
Updated: May 13, 2026

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro
Published on: January 31, 2022
The liver toxicity knowledge base: a systems approach to a complex end point
1Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, Arkansas, USA.
Abstract:
Drug-induced liver injury (DILI) is a major concern in public health management, drug development, and regulatory implementation. The Liver Toxicity Knowledge Base (LTKB) was developed with the specific aim of enhancing our understanding of DILI. It seeks to achieve improvement in DILI prediction through integrated analysis of diverse sources of drug-elicited data. The project has also produced a centralized resource of data as well as predictive models that will be useful for research and drug regulation.
Related Concept Videos
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test
Toxicokinetics: Overview
Toxic Reactions: Overview
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
Drug Toxicity: Overview
Drug Toxicity: Dose-Dependent Reactions
Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow

